Targeted Protein Degradation: Principles and Applications of the Proteasome

卷:12

Review

关键词: UBIQUITIN-INDEPENDENT DEGRADATION;    DEPENDENT PROTEOLYTIC SYSTEM;    OXIDIZED PROTEINS;    DOWN-REGULATION;    26S PROTEASOME;    ACTIVATOR PA28;    E3 LIGASE;    ORNITHINE-DECARBOXYLASE;    20S PROTEASOME;    CDNA CLONING;   

DOI  :  10.3390/cells12141846

来源: SCIE

【 摘 要 】

The proteasome is a multi-catalytic protease complex that is involved in protein quality control via three proteolytic activities (i.e., caspase-, trypsin-, and chymotrypsin-like activities). Most cellular proteins are selectively degraded by the proteasome via ubiquitination. Moreover, the ubiquitin-proteasome system is a critical process for maintaining protein homeostasis. Here, we briefly summarize the structure of the proteasome, its regulatory mechanisms, proteins that regulate proteasome activity, and alterations to proteasome activity found in diverse diseases, chemoresistant cells, and cancer stem cells. Finally, we describe potential therapeutic modalities that use the ubiquitin-proteasome system.