Enzymology of Ca2+-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases

卷:12

Review

关键词: CYCLIC ADP-RIBOSE;    ADENINE-DINUCLEOTIDE PHOSPHATE;    PYRIDINE-NUCLEOTIDE CYCLE;    REGULATES INTRACELLULAR CALCIUM;    HYDROGEN-PEROXIDE;    CA2+ MOBILIZATION;    MICE DEFICIENT;    OUTER SURFACE;    CD38 ENZYME;    NAADP;   

DOI  :  10.3390/cells12040675

来源: SCIE

【 摘 要 】

Nicotinamide adenine dinucleotide (NAD) and its 2 '-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca2+-mobilizing second messengers adenosine diphosphoribose (ADPR), 2 '-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine dinucleotide phosphate (NAADP). The enzymes involved are either NAD glycohydrolases CD38 or sterile alpha toll/interleukin receptor motif containing-1 (SARM1), or (dual) NADPH oxidases (NOX/DUOX). Enzymatic function(s) are reviewed and physiological role(s) in selected cell systems are discussed.