卷:12 | |
PD-L1's Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant | |
Review | |
关键词: VERSUS-HOST-DISEASE; CONSENSUS DEVELOPMENT PROJECT; BONE-MARROW-TRANSPLANTATION; NATURAL-KILLER-CELLS; ANTIGEN-PRESENTING CELLS; MURINE CHRONIC GVHD; PROGRAMMED DEATH-1; GRAFT-REJECTION; CLINICAL-TRIALS; DENDRITIC CELLS; | |
DOI : 10.3390/cells12121609 | |
来源: SCIE |
【 摘 要 】
Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), followed by a summary of biologically relevant molecular interactions of both PD-L1 and Programmed Cell Death Protein 1 (PD-1). Finally, we present a translational perspective on how PD-L1 can interrupt alloreactive-driven processes to increase immune tolerance. Unlike most current therapies that block PD-L1 and/or its interaction with PD-1, this review focuses on how upregulation or reversed sequestration of this ligand may reduce autoimmunity, ameliorate GVHD, and enhance graft survival following organ transplant.
【 授权许可】