Essential Role of Multi-Omics Approaches in the Study of Retinal Vascular Diseases

卷:12

Review

关键词: GENOME-WIDE ASSOCIATION;    ENDOTHELIAL GROWTH-FACTOR;    DIABETIC-RETINOPATHY;    MACULAR DEGENERATION;    RISK-FACTORS;    AFLIBERCEPT INTERVENTION;    INTRAVITREAL AFLIBERCEPT;    SYSTEMS BIOLOGY;    BIOMARKERS;    BEVACIZUMAB;   

DOI  :  10.3390/cells12010103

来源: SCIE

【 摘 要 】

Retinal vascular disease is a highly prevalent vision-threatening ocular disease in the global population; however, its exact mechanism remains unclear. The expansion of omics technologies has revolutionized a new medical research methodology that combines multiple omics data derived from the same patients to generate multi-dimensional and multi-evidence-supported holistic inferences, providing unprecedented opportunities to elucidate the information flow of complex multi-factorial diseases. In this review, we summarize the applications of multi-omics technology to further elucidate the pathogenesis and complex molecular mechanisms underlying retinal vascular diseases. Moreover, we proposed multi-omics-based biomarker and therapeutic strategy discovery methodologies to optimize clinical and basic medicinal research approaches to retinal vascular diseases. Finally, the opportunities, current challenges, and future prospects of multi-omics analyses in retinal vascular disease studies are discussed in detail.