The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

卷:12

Review

关键词: NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;    COLORECTAL-CANCER;    ADIPOSE-TISSUE;    CHEMERIN/CHEMR23 AXIS;    THERAPEUTIC TARGETS;    MULTIFACETED ROLES;    SIGNALING PATHWAYS;    GENE POLYMORPHISM;    BODY-TEMPERATURE;    POOR-PROGNOSIS;   

DOI  :  10.3390/cells12081118

来源: SCIE

【 摘 要 】

Due to their multidirectional influence, adipocytokines are currently the subject of numerous intensive studies. Significant impact applies to many processes, both physiological and pathological. Moreover, the role of adipocytokines in carcinogenesis seems particularly interesting and not fully understood. For this reason, ongoing research focuses on the role of these compounds in the network of interactions in the tumor microenvironment. Particular attention should be drawn to cancers that remain challenging for modern gynecological oncology-ovarian and endometrial cancer. This paper presents the role of selected adipocytokines, including leptin, adiponectin, visfatin, resistin, apelin, chemerin, omentin and vaspin in cancer, with a particular focus on ovarian and endometrial cancer, and their potential clinical relevance.