Identification of Exo-miRNAs: A Summary of the Efforts in Translational Studies Involving Triple-Negative Breast Cancer

卷:12

Review

关键词: FUNCTIONAL MICRORNA TARGETS;    NORMALIZATION STRATEGIES;    EXTRACELLULAR VESICLES;    EXOSOMES;    BIOGENESIS;    BIOMARKER;    METASTASIS;    EXPRESSION;    PLASMA;    PROGRESSION;   

DOI  :  10.3390/cells12091339

来源: SCIE

【 摘 要 】

Triple-negative breast cancer (TNBC) accounts for about 10-15% of all breast cancers (BC) in the US and its diagnosis is associated with poor survival outcomes. A better understanding of the disease etiology is crucial to identify target treatment options to improve patient outcomes. The role of exo-miRNAs in TNBC has been studied for more than two decades. Although some studies have identified exo-miR candidates in TNBC using clinical samples, consensus regarding exo-miR candidates has not been achieved. The purpose of this review is to gather information regarding exo-miR candidates reported in TNBC translational studies along with the techniques used to isolate and validate the potential targets. The techniques suggested in this review are based on the use of commercially available materials for research and clinical laboratories. We expect that the information included in this review can add additional value to the recent efforts in the development of a liquid biopsy to identify TNBC cases and further improve their survival outcomes.