The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research

卷:12

Review

关键词: CYCLIC-ADP-RIBOSE;    ADENINE DINUCLEOTIDE PHOSPHATE;    SMOOTH-MUSCLE-CELLS;    ACUTE KIDNEY INJURY;    NF-KAPPA-B;    CELLULAR NAD;    NICOTINAMIDE MONONUCLEOTIDE;    RENAL VASOCONSTRICTION;    OXIDATIVE STRESS;    ANGIOTENSIN-II;   

DOI  :  10.3390/cells12040595

来源: SCIE

【 摘 要 】

Aging is a major risk factor for the leading causes of mortality, and the incidence of age-related diseases including cardiovascular disease, kidney disease and metabolic disease increases with age. NAD(+) is a classic coenzyme that exists in all species, and that plays a crucial role in oxidation-reduction reactions. It is also involved in the regulation of many cellular functions including inflammation, oxidative stress and differentiation. NAD(+) declines with aging in various organs, and the reduction in NAD(+) is possibly involved in the development of age-related cellular dysfunction in cardiorenal metabolic organs through the accumulation of inflammation and oxidative stress. Levels of NAD(+) are regulated by the balance between its synthesis and degradation. CD38 is the main NAD(+)-degrading enzyme, and CD38 is activated in response to inflammation with aging, which is associated with the reduction in NAD(+) levels. In this review, focusing on CD38, we discuss the role of CD38 in aging and the pathogenesis of age-related diseases, including cardiorenal metabolic disease.