Integrating Ion Channels with Bioelectronics for Biotic-Abiotic Systems

Review; Early Access

关键词: SUPPORTED LIPID-BILAYERS;    QUARTZ-CRYSTAL MICROBALANCE;    LABEL-FREE;    MEMBRANE;    TRANSPORT;    IMPEDANCE;    DEVICES;    GRAMICIDIN;    BIOSENSORS;    MODEL;   

DOI  :  10.1002/aisy.202200312

来源: SCIE

【 摘 要 】

Precise and highly regulated flow of biomolecules and ions through complex cellular networks is crucial for communication and information processing in living systems. In contrast, human-made electronics rely on the flow of electrons and holes through well-defined semiconductor networks for processing. Ion channels play vital roles in regulating the flow of ions and biomolecules across the cell membrane with a complexity unmatched in any semiconductor device. To enable biotic-abiotic communication and leverage this complexity, supported lipid bilayers (SLBs) create a planar cell membrane for integration with bioelectronics. This review discusses the integration of ion channels in bioelectronic devices for biotic-abiotic communication with enhanced functionality. This review begins with an introduction of natural and artificial ion channels across SLBs, continues with a description of bioelectronic devices integrating SLBs, and concludes with examples of functional ion channel bioelectronics.