Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases

卷:46

Review

关键词: GMP-AMP SYNTHASE;    TO-AUTOINTEGRATION FACTOR;    DOUBLE-STRANDED DNA;    STING AGONIST;    AUTOIMMUNE-DISEASE;    MITOCHONDRIAL DAMAGE;    INSULIN-RESISTANCE;    MOUSE MODEL;    DI-GMP;    CGAS;   

DOI  :  10.1007/s12272-023-01452-3

来源: SCIE

【 摘 要 】

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic microorganisms. cGAS/STING is positioned as a key axis of autoimmunity, the inflammatory response, and cancer progression, suggesting that the cGAS/STING signaling pathway represents an efficient therapeutic target. Based on the accumulated evidence, we present insights into the prevention and treatment of cGAS/STING-related chronic immune and inflammatory diseases. This review presents the current state of clinical and nonclinical development of modulators targeting cGAS/STING, providing useful information on the design of therapeutic strategies.

【 授权许可】

Free