Ready-To-Use and Rapidly Biodegradable Magnesium Phosphate Bone Cement: In Vivo Evaluation in Sheep

Article; Early Access

关键词: BETA-TRICALCIUM PHOSPHATE;    CALCIUM;    RESORPTION;    REGENERATION;    DEFECT;    INJECTABILITY;    DEGRADATION;    BRUSHITE;    BEHAVIOR;    VITRO;   

DOI  :  10.1002/adhm.202300914

来源: SCIE

【 摘 要 】

In clinical practice, hydroxyapatite (HA) cements for bone defect treatment are frequently prepared by mixing a powder component and a liquid component shortly before implantation in the operation theater, which is time-consuming and error-prone. In addition, HA cements are only slightly resorbed, that is, cement residues can still be found in the bone years after implantation. Here, these challenges are addressed by a prefabricated magnesium phosphate cement paste based on glycerol, which is ready-to-use and can be directly applied during surgery. By using a trimodal particle size distribution (PSD), the paste is readily injectable and exhibits a compressive strength of 9-14 MPa after setting. Struvite (MgNH4PO4 center dot 6H(2)O), dittmarite (MgNH4PO4 center dot H2O), farringtonite (Mg-3(PO4)(2)), and newberyite (MgHPO4 center dot 3H(2)O) are the mineral phases present in the set cement. The paste developed here features a promising degradation of 37% after four months in an ovine implantation model, with 25% of the implant area being newly formed bone. It is concluded that the novel prefabricated paste improves application during surgery, has a suitable degradation rate, and supports bone regeneration.

【 授权许可】

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