Sustainable Sources of Raw Materials for Additive Manufacturing of Bone-Substituting Biomaterials

Review; Early Access

关键词: CALCIUM-PHOSPHATE BIOCERAMICS;    IN-VITRO BIOACTIVITY;    RICE HUSK ASH;    SILK FIBROIN;    FISH SCALE;    TRICALCIUM PHOSPHATE;    EGGSHELL WASTE;    HYDROXYAPATITE;    SCAFFOLDS;    COLLAGEN;   

DOI  :  10.1002/adhm.202301837

来源: SCIE

【 摘 要 】

The need for sustainable development has never been more urgent, as the world continues to struggle with environmental challenges, such as climate change, pollution, and dwindling natural resources. The use of renewable and recycled waste materials as a source of raw materials for biomaterials and tissue engineering is a promising avenue for sustainable development. Although tissue engineering has rapidly developed, the challenges associated with fulfilling the increasing demand for bone substitutes and implants remain unresolved, particularly as the global population ages. This review provides an overview of waste materials, such as eggshells, seashells, fish residues, and agricultural biomass, that can be transformed into biomaterials for bone tissue engineering. While the development of recycled metals is in its early stages, the use of probiotics and renewable polymers to improve the biofunctionalities of bone implants is highlighted. Despite the advances of additive manufacturing (AM), studies on AM waste-derived bone-substitutes are limited. It is foreseeable that AM technologies can provide a more sustainable alternative to manufacturing biomaterials and implants. The preliminary results of eggshell and seashell-derived calcium phosphate and rice husk ash-derived silica can likely pave the way for more advanced applications of AM waste-derived biomaterials for sustainably addressing several unmet clinical applications.

【 授权许可】

Free