Association between triglyceride-glucose index trajectories and carotid atherosclerosis progression

Cardiovascular Diabetology

Research

Wei Gao¹  Lincheng Yang¹  Dan Liu¹  Haixu Yu¹  Yan-Guang Li¹  Wei Zhao²  Xiaoyan Hao³  Peng Wang³  Honghai He³  Ying Che³  Yang Wang³  Liyuan Tao⁴ 

[1] NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Department of Cardiology, Institute of Vascular Medicine, Ministry of Education, Peking University Third Hospital, 100191, Beijing, China;NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Department of Cardiology, Institute of Vascular Medicine, Ministry of Education, Peking University Third Hospital, 100191, Beijing, China;Physical Examination Center, Peking University Third Hospital, 100191, Beijing, China;Physical Examination Center, Peking University Third Hospital, 100191, Beijing, China;Research Center of Clinical Epidemiology, Peking University Third Hospital, 100191, Beijing, China;

关键词: Triglyceride-glucose index;    Insulin resistance;    Carotid atherosclerosis;    Progression;    Longitudinal study;   

DOI  :  10.1186/s12933-023-01847-y

 received in 2023-02-27, accepted in 2023-05-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe triglyceride-glucose (TyG) index has been recognized as being an alternative cardiometabolic biomarker for insulin resistance associated with the development and prognosis of cardiovascular disease (CVD). However, the prospective relationship between baseline and long-term trajectories of the TyG index and carotid atherosclerosis (CAS) progression has yet to be investigated.MethodsThis longitudinal prospective cohort study included 10,380 adults with multiple general health checks at Peking University Third Hospital from January 2011 to December 2020. The TyG index was calculated as ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). The latent class trajectory modeling method was used to analyze the TyG index trajectories over the follow-up. Based on univariate and multivariate Cox proportional hazards analyses, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for the baseline and trajectory of the TyG index.ResultsDuring a median follow-up period of 757 days, 1813 participants developed CAS progression. Each 1-standard deviation (SD) increase in the TyG index was associated with a 7% higher risk of CAS progression after adjusting for traditional CVD risk factors (HR = 1.067, 95% CI 1.006–1.132). Similar results were observed when the TyG index was expressed as quartiles. According to different trajectory patterns, participants were categorized into low-stable, moderate-stable, and high-increasing groups. After multivariate adjustment, the moderate-stable group had a 1.139-fold (95% CI 1.021–1.272) risk of CAS progression. The high-increasing trajectory of the TyG index tended to be associated with CAS progression (HR = 1.206, 95% CI 0.961–1.513).ConclusionsParticipants with higher baseline and moderate-stable trajectory of the TyG index were associated with CAS progression. Long-term trajectories of the TyG index can help to identify individuals at a higher risk of CAS progression who deserve specific preventive and therapeutic approaches.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3

40517_2023_252_Article_IEq73.gif

40517_2023_252_Article_IEq69.gif

Fig. 1