Clinical prognosis and related molecular features of hepatitis B-associated adolescent and young adult hepatocellular carcinoma

Human Genomics

Research

Chenhao Jiang¹  Xi Xu¹  Daofeng Zheng¹  Tao Lv¹  Diao He¹  Bo Zhang²  Yongjie Zhou³  Jiayin Yang³ 

[1] Department of Liver Transplant Center, Transplant Center & Lab of Liver Transplantation, West China Hospital of Sichuan University, Sichuan University, 610041, Chengdu, China;Department of Liver Transplant Center, Transplant Center & Lab of Liver Transplantation, West China Hospital of Sichuan University, Sichuan University, 610041, Chengdu, China;Department of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan University, 610041, Chengdu, China;Department of Liver Transplant Center, Transplant Center & Lab of Liver Transplantation, West China Hospital of Sichuan University, Sichuan University, 610041, Chengdu, China;Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital of Sichuan University, Sichuan University, 610041, Chengdu, China;

关键词: AYA HCC;    Whole transcriptome sequencing;    MPIs;    Fatty acid metabolism;    ceRNA;   

DOI  :  10.1186/s40246-023-00500-9

 received in 2023-03-04, accepted in 2023-06-06,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundInattention has been given to the pathogenesis of adolescent and young adult (AYA) hepatocellular carcinoma (HCC). Due to the more advanced tumor progression and poorer prognosis of AYA-HCC, together with a better tolerance ability, noncirrhotic background, and a stronger willingness to treat AYA-HCC, clinical and molecular biology studies are urgent and necessary, especially for those with hepatitis B infection.MethodsFor clinical aspects, the overall survival, the recurrence-free survival, and the Cox analyses were performed. Then, functional analysis, gene clustering, metabolic-related analysis, immune infiltration and competing endogenous RNA (ceRNA) construction were carried out using whole transcriptome sequencing technique.ResultsBased on the clinical information of our HCC cohort, the overall survival and recurrence-free survival rates were worse in the AYA group than in the elderly group as previously described. According to our whole transcriptome sequencing results, functional analysis revealed that metabolism-related pathways as well as protein translation and endoplasmic reticulum processing were enriched. Then the hub metabolism-related genes were screened by metabolite–protein interactions (MPIs) and protein–protein interactions (PPIs). Fatty acid metabolism is a crucial component of metabolic pathways, abnormalities of which may be the reason for the worse prognosis of HBV-AYA HCC. Finally, the relationship of disrupted expression of metabolism-related genes with immune infiltration was also analyzed, and the lncRNA‒miRNA‒mRNA-related ceRNA network for HBV-AYA HCC was constructed, which may provide new cues for HBV-AHA HCC prevention.ConclusionThe worse prognosis and recurrence rate of HBV-AYA HCC may be related to abnormalities in metabolism-related pathways, especially disorders of fatty acid metabolism.

【 授权许可】

CC BY   
© The Author(s) 2023

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