Unique features of the arterial blood–brain barrier

Fluids and Barriers of the CNS

Research

Shira Anzi¹  Ayal Ben-Zvi¹  Esther Sasson¹  Batia Bell¹ 

[1] Department of Developmental Biology and Cancer Research, Faculty of Medicine, Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, The Institute for Medical Research Israel-Canada, Hebrew University of Jerusalem, 91120, Jerusalem, Israel;

关键词: BBB;    Arterial berrier;    Super-resolution;    dSTORM;    Transcytosis;   

DOI  :  10.1186/s12987-023-00450-3

 received in 2022-12-11, accepted in 2023-06-05,  发布年份 2023

来源: Springer

【 摘 要 】

CNS vasculature differs from vascular networks of peripheral organs by its ability to tightly control selective material exchange across capillary barriers. Capillary permeability is mostly defined by unique cellular components of the endothelium. While capillaries are extensively investigated, the barrier properties of larger vessels are understudied. Here, we investigate barrier properties of CNS arterial walls. Using tracer challenges and various imaging modalities, we discovered that at the mouse cortex, the arterial barrier does not reside at the classical level of the endothelium. The arterial wall’s unique permeability acts bi-directionally; CSF substances travel along the glymphatic path and can penetrate from the peri-vascular space through arteriolar walls towards the lumen. We found that caveolae vesicles in arteriole endothelial are functional transcytosis machinery components, and that a similar mechanism is evident in the human brain. Our discoveries highlight vascular heterogeneity investigations as a potent approach to uncover new barrier mechanisms.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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