A prospective clinical study evaluating short-term changes in body composition and quality of life after gastrectomy in elderly patients receiving postoperative exercise and nutritional therapies

BMC Surgery

Research

Seijiro Yoshifuku¹  Masatake Miyamoto¹  Kotaro Sasahara¹  Yasunori Nishida¹  Katsunori Tauchi¹  Akira Kameyama¹  Noriaki Otagiri¹  Mai Tokunaga² 

[1]Department of Surgery, Aizawa Hospital, 2-5-1 Honjou Matsumoto, 390-8510, Nagano, Japan

[2]Rehabilitation Center, Aizawa Hospital, 2-5-1 Honjou Matsumoto, 390-8510, Nagano, Japan

关键词: Gastric cancer;    Body composition;    Elderly;    BCAA;    Rehabilitation;   

DOI  :  10.1186/s12893-023-02086-4

 received in 2023-01-10, accepted in 2023-06-20,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMuscle mass loss after gastrectomy is associated with a negative impact on quality of life (QOL) and long-term prognosis following gastric cancer treatment, especially in elderly patients. We conducted a prospective study to examine short-term changes in body composition and QOL after gastrectomy in elderly patients with gastric cancer who received exercise and nutritional therapies.MethodsPatients over aged 65 years of age who underwent gastrectomies for gastric cancer were enrolled in our study. Patients received exercise and nutritional therapies with branched-chain amino acid (BCAA)-rich supplements during 1 month after surgery. Body composition was evaluated using InBody S10 before surgery, and at 1 week and 1 month postoperatively. Other variables including QOL status (EQ-5D-5 L), serum albumin level, hand grip strength, and gait speed were evaluated at the same time.ResultsEighteen patients were analyzed. The mean loss of skeletal muscle mass index (SMI) was 4.6% (1 week) and 2.1% (1 month) compared to the preoperative period. QOL scores showed almost the same degree of recovery at 1 month after gastrectomy as preoperative scores. Serum albumin levels, hand grip strength, and gait speed decreased at 1 week and then increased at 1 month after surgery, similar to the changes seen in SMI.ConclusionsMultidisciplinary approaches play key role in the surgical treatment of elderly patients. Postoperative exercise and nutritional therapies with BCAA-rich supplements may benefit elderly patients after gastrectomy by reducing loss of SMI and decreases in QOL.Trial registrationUMIN Clinical Trials Registry; UMIN000034374 (registration date: 10/10/2018).

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

40517_2023_259_Article_IEq31.gif

40517_2023_259_Article_IEq28.gif

Fig. 2

Fig. 1

42004_2023_919_Article_IEq175.gif