Outcomes following transcatheter repair in patients with functional mitral regurgitation not receiving guideline directed medical therapy in Israel

BMC Cardiovascular Disorders

Research

David Planer¹  Ronen Beeri¹  David Leibowitz²  Dan Haberman³  Sorel Goland³  Jacob George³  Mony Shuvy⁴  Rafael Wolf⁴  Becky Kutsher⁴  Tal Hasin⁴ 

[1]Department of Cardiology, Faculty of Medicine Hadassah, Hebrew University Medical Center, Jerusalem, Israel

[2]Department of Cardiology, Faculty of Medicine Hadassah, Hebrew University Medical Center, Jerusalem, Israel

[3]Coronary Care Unit, Hadassah Medical Center Mount Scopus Jerusalem, Jerusalem, Israel

[4]Department of Cardiology, Kaplan Medical Center, Rehovot, Israel

[5]Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel

关键词: Mitral regurgitation;    Transcatheter repair;    Congestive heart failure;   

DOI  :  10.1186/s12872-023-03344-2

 received in 2022-11-17, accepted in 2023-06-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTranscatheter edge to edge repair (TEER) improves prognosis in patients with functional mitral regurgitation (FMR) receiving guideline directed medical therapy (GDMT). Many patients with FMR do not receive GDMT and the utility of TEER in this population remains unclear.MethodsWe retrospectively studied patients undergoing TEER. Clinical, echocardiographic and procedural variables were recorded. GDMT was defined as use of RAAS inhibitors and MRAs unless GFR was under 30 as well as beta blockers. The primary endpoint of the study was one year mortality.Results168 patients (mean age 71.3 ± 9.3; 66% males) with FMR who underwent TEER were included of whom 116 (69%) received GDMT at the time of TEER and 52 (31%) did not. There were no significant demographic or clinical differences between the groups. There were no significant differences in procedural success and complications between groups. One year mortality was identical in the two groups (15% vs. 15%; RR 1.06, CI 0.43–2.63, P = 0.90).ConclusionsOur findings suggest that procedural success and one year mortality following TEER was not significantly different in HFREF patients with FMR with or without GDMT. Larger, prospective studies are necessary to define the benefit of TEER in this population.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1

Fig. 3

12968_2023_940_Article_IEq3.gif

Fig. 3