Impact of Exercise in Hypoxia on Inflammatory Cytokines in Adults: A Systematic Review and Meta-analysis

Sports Medicine - Open

Systematic Review

Michael E. Symonds¹  Mohammad Hossein Sakhaei²  Saeid Reza Noori Mofrad³  Mousa Khalafi³  Yubo Liu⁴  Mallikarjuna Korivi⁴ 

[1] Centre for Perinatal Research, Academic Unit of Population and Lifespan Sciences, School of Medicine, University of Nottingham, NG7 2UH, Nottingham, UK;Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Guilan, Iran;Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran;Institute of Human Movement and Sports Engineering, College of Physical Education and Health Sciences, Zhejiang Normal University, 321004, Jinhua City, Zhejiang, China;

关键词: Exercise;    Hypoxia;    Inflammatory cytokines;    IL-6;    TNF-α;    IL-10;   

DOI  :  10.1186/s40798-023-00584-6

 received in 2022-11-22, accepted in 2023-05-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundBoth acute exercise and environmental hypoxia may elevate inflammatory cytokines, but the inflammatory response in the hypoxic exercise is remaining unknown.ObjectiveWe performed this systematic review and meta-analysis to examine the effect of exercise in hypoxia on inflammatory cytokines, including IL-6, TNF-α and IL-10.MethodsPubMed, Scopus and Web of Science were searched to identify the original articles that compared the effect of exercise in hypoxia with normoxia on IL-6, TNF-α and IL-10 changes, published up to March 2023. Standardized mean differences and 95% confidence intervals (CIs) were calculated using a random effect model to (1) determine the effect of exercise in hypoxia, (2) determine the effect of exercise in normoxia and (3) compare the effect of exercise in hypoxia with normoxia on IL-6, TNF-α and IL-10 responses.ResultsTwenty-three studies involving 243 healthy, trained and athlete subjects with a mean age range from 19.8 to 41.0 years were included in our meta-analysis. On comparing exercise in hypoxia with normoxia, no differences were found in the response of IL-6 [0.17 (95% CI − 0.08 to 0.43), p = 0.17] and TNF-α [0.17 (95% CI − 0.10 to 0.46), p = 0.21] between the conditions. Exercise in hypoxia significantly increased IL-10 concentration [0.60 (95% CI 0.17 to 1.03), p = 0.006] compared with normoxia. In addition, exercise during both hypoxia and normoxia increased IL-6 and IL-10, whereas TNF-α was increased only in hypoxic exercise condition.ConclusionOverall, exercise in both hypoxia and normoxia increased inflammatory cytokines; however, hypoxic exercise may lead to a greater inflammatory response in adults.

【 授权许可】

CC BY   
© The Author(s) 2023

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