Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice

AMB Express

Original Article

Puyu Zhang¹  Dalong Liao¹  Linman Li¹  Hui Zhu¹  Xiongjun Xiao¹  Chaohua Lan¹  Kewei Xu¹  Shan Mo¹  Xiaoli Zhou¹  Baoxiang Gu¹  Muhammad Aamer Mehmood²  Ning Wang³  Manli He⁴  Tao Wu⁵ 

[1] College of Bioengineering, Sichuan University of Science and Engineering, 643000, Zigong, China;College of Bioengineering, Sichuan University of Science and Engineering, 643000, Zigong, China;Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan;College of Bioengineering, Sichuan University of Science and Engineering, 643000, Zigong, China;Luzhou Laojiao Co. Ltd, Luzhou, China;College of Horticulture, Hunan Agricultural University, Changsha, China;Laboratory Animal Center, Southwest Medical University, Luzhou, Sichuan, China;School of Food and Biological Engineering, Xihua University, 610039, Chengdu, China;

关键词: Tea polyphenols;    Intestinal microbiota;    Lipid metabolism;    Antioxidative;   

DOI  :  10.1186/s13568-023-01565-4

 received in 2022-12-27, accepted in 2023-05-23,  发布年份 2023

来源: Springer

【 摘 要 】

Tea polyphenols (TP) are the most biologically active components in tea, with antioxidant, antiobesity, and antitumor properties, as well as the ability to modulate the composition and function of intestinal microbiota. This experimental study evaluated the chemical constituents of polyphenols in Pu-erh (PTP) and Dian Hong tea (DHTP). It also investigated the co-regulatory effects of PTP and DHTP on intestinal flora and liver tissues in mice using 16 S rRNA gene and transcriptome sequencing. The results revealed that DHT had higher concentrations of EGC (epigallocatechin), C (catechin), EC (epicatechin), and EGCG (epigallocatechin gallate). In contrast, PT had higher concentrations of GA (gallic acid), ECG (epicatechin-3-gallate), TF (theaflavin), and TB (theabrownin). PTP and DHTP consumption significantly reduced the rates of weight gain in mice. Microbial community diversity was significantly higher in PTP and DHTP-treated mice than in the control group. Notably, beneficial microbes such as Lactobacillus increased significantly in PTP-treated mice, whereas Lachnospiraceae increased significantly in DHTP-treated mice. Both PTP and DHTP improved the activity of the antioxidant enzymes (SOD) and total antioxidant capacity (T-AOC) in the liver. The transcriptome analysis revealed that the beneficial effects of PTP and DHTP were due to changes in various metabolic pathways, the majority of which were related to antioxidant and lipid metabolism. This study discovered that PTP and DHTP had beneficial effects in mice via the gut-liver axis.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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