Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

Communications Biology

Article

Yelin Dai¹  Junlin Chen¹  Zhihua Luo¹  Li Zhang²  Kwok-Fai So³ 

[1] Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China;Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China;Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, China;Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China;Center for Exercise and Brain Science, School of Psychology, Shanghai University of Sport, Shanghai, China;Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China;State Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China;Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, China;Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China;Center for Exercise and Brain Science, School of Psychology, Shanghai University of Sport, Shanghai, China;

关键词: ;   

DOI  :  10.1038/s42003-023-05003-w

 received in 2022-11-21, accepted in 2023-05-31,  发布年份 2023

来源: Springer

【 摘 要 】

Aerobic exercise effectively ameliorates mental disorders including anxiety and depression. Current findings mainly attribute its neural mechanism to the improvement of adult neurogenesis, while leaving the possible circuitry mechanism unclear. In the current study, we identify the overexcitation of the medial prefrontal cortex (mPFC) to basolateral amygdala (BLA) pathway under chronic restraint stress (CRS), and 14-day treadmill exercise selectively reverses such abnormalities. Using chemogenetic approaches, we find that the mPFC-BLA circuit is necessary for preventing anxiety-like behaviors in CRS mice. These results collectively suggest a neural circuitry mechanism by which exercise training improves the resilience against environmental stress.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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