Immunotherapy with Pru p 3 for food allergy to peach and non-specific lipid transfer protein: a systematic review

Clinical and Molecular Allergy

Review

Gian Luigi Marseglia¹  Amelia Licari¹  Carlo Maria Rossi²  Marco Vincenzo Lenti²  Antonio Di Sabatino³  Stefania Merli⁴ 

[1] Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy;Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy;First Department of Internal Medicine, Fondazione IRCCS San Matteo, Pavia, Italy;Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy;First Department of Internal Medicine, Fondazione IRCCS San Matteo, Pavia, Italy;Clinica Medica I, Fondazione IRCCS Policlinico San Matteo, Università Di Pavia, Viale Golgi 19, 27100, Pavia, Italy;First Department of Internal Medicine, Fondazione IRCCS San Matteo, Pavia, Italy;

关键词: Diet;    Food allergy;    Immunotherapy;    Non-specific lipid transfer protein;    Peach;   

DOI  :  10.1186/s12948-023-00184-5

 received in 2022-10-31, accepted in 2023-03-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundNon-specific lipid-transfer protein (nsLTP) is a pan-allergen in the plant world, and a cause of significant concern as food allergen in the Mediterranean area, due to its general heat- and acid-resistance and hence the risk of severe allergic reactions. Pru p 3, the peach nsLTP, is considered the primary sensitizer to this allergen family and this allergy is usually persistent. Allergen-free diet and acute treatment of manifestations are the main recognized management goals in food allergy.Main textThe role of immunotherapy for treating food allergy in adult patients is controversial, but immunotherapy for Pru p 3 could potentially represent a relevant therapeutic strategy. We systematically searched databases for studies assessing the role of immunotherapy Pru p 3 in food allergy. Overall, nine studies were included. Immunotherapy with Pru p 3 appears to be effective and with a good safety profile in both peach and LTP allergy for some foods, such as peanut, in both RCT and real-life studies.ConclusionsImmunotherapy with Pru p 3 is a possible treatment option for food allergy to the peach LTP in the Mediterranean area, although at present have not reached routinary clinical practice. Larger studies are needed to confirm these findings and identify predictive biomarkers.

【 授权许可】

CC BY   
© The Author(s) 2023

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