Accessing hepatitis C direct acting antivirals among people living with hepatitis C: a qualitative study

International Journal for Equity in Health

Research

Mina Tadrous¹  Dana Shearer²  Cheryl Pritlove³  Tony Antoniou⁴  Tara Gomes⁵  Hemant Shah⁶ 

[1] Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada;Women’s College Research Institute, Toronto, ON, Canada;Li Ka Shing Knowledge Institute, Unity Health, Toronto, ON, Canada;Li Ka Shing Knowledge Institute, Unity Health, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;Li Ka Shing Knowledge Institute, Unity Health, Toronto, ON, Canada;Department of Family and Community Medicine, Unity Health, Toronto, ON, Canada;Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada;Li Ka Shing Knowledge Institute, Unity Health, Toronto, ON, Canada;Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada;Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada;Toronto Centre for Liver Disease, University Health Network, Toronto, ON, Canada;Department of Medicine, University of Toronto, Toronto, ON, Canada;

关键词: Direct acting antivirals;    Hepatitis C;    People who inject drugs;    Qualitative research;   

DOI  :  10.1186/s12939-023-01924-4

 received in 2022-12-06, accepted in 2023-05-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHepatitis C is curable with direct-acting antivirals (DAAs). However, treatment uptake remains low among marginalized populations such as people who inject drugs. We sought to understand challenges to treatment uptake with DAAs among people living with hepatitis C and compare treatment experiences between people who do and do not inject prescription and/or unregulated drugs.MethodsWe conducted a qualitative study using focus groups with 23 adults aged 18 years and over who completed DAA treatment or were about to begin such treatment at the time of the study. Participants were recruited from hepatitis C treatment clinics across Toronto, Ontario. We drew upon stigma theory to interpret participants’ accounts.ResultsFollowing analysis and interpretation, we generated five theoretically-informed themes characterizing the experiences of individuals accessing DAAs: “being ‘worthy’ of the cure”, “spatially enacted stigma”, “countering social and structural vulnerability: the importance of peers”, “identity disruption and contagion: attaining a ‘social cure’” and “challenging stigma with population-based screening”. Overall, our findings suggest that structural stigma generated and reproduced through healthcare encounters limits access to DAAs among people who inject drugs. Peer-based programs and population-based screening were proposed by participants as mechanisms for countering stigma within health care settings and ‘normalizing’ hepatitis C among the general population.ConclusionsDespite the availability of curative therapies, access to such treatment for people who inject drugs is limited by stigma enacted in and structured within healthcare encounters. Developing novel, low-threshold delivery programs that remove power differentials and attend to the social and structural determinants of health and reinfection are needed to facilitate further scale up of DAAs and support the goal of eradicating hepatitis C as a public health threat.

【 授权许可】

CC BY   
© The Author(s) 2023