Causal associations between chronic hepatitis B and COVID-19 in East Asian populations

Virology Journal

Research

Yuhao Wang¹  Yongjun Zhou¹  Libo Tang¹  Junling Chen¹  Zhenguo Liu¹  Linnan Song¹  Yongyin Li¹ 

[1] State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, 510515, Guangzhou, China;

关键词: Chronic hepatitis B (CHB);    Coronavirus disease 2019 (COVID-19);    Causal effect;    Mendelian randomization (MR);   

DOI  :  10.1186/s12985-023-02081-4

 received in 2023-03-03, accepted in 2023-05-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe relationship between chronic hepatitis B (CHB) and Coronavirus disease 2019 (COVID-19) has been inconsistent in traditional observational studies.MethodsWe explored the total causal and direct causal associations between CHB and the three COVID-19 outcomes using univariate and multivariate Mendelian randomization (MR) analyses, respectively. Genome-wide association study datasets for CHB and COVID-19 were obtained from the Japan Biobank and the COVID-19 Host Genetics Initiative, respectively.ResultsUnivariate MR analysis showed that CHB increased the risk of SARS-CoV-2 infection (OR = 1.04, 95% CI 1.01–1.07, P = 3.39E−03), hospitalized COVID-19 (OR = 1.10, 95% CI 1.06–1.13, P = 7.31E−08), and severe COVID-19 (OR = 1.16, 95%CI 1.08–1.26, P = 1.43E−04). A series of subsequent sensitivity analyses ensured the stability and reliability of these results. In multivariable MR analyses adjusting for type 2 diabetes, body mass index, basophil count, and smoking, genetically related CHB is still positively associated with increased risk of SARS-CoV-2 infection (OR = 1.06, 95% CI 1.02–1.11, P = 1.44E−03) and hospitalized COVID-19 (OR = 1.12, 95% CI 1.07–1.16, P = 5.13E−07). However, the causal link between CHB and severe COVID-19 was attenuated after adjustment for the above variables. In addition, the MR analysis did not support the causal effect of COVID-19 on CHB.ConclusionsThis study provides evidence that CHB increases COVID-19 susceptibility and severity among individuals of East Asian ancestry.

【 授权许可】

CC BY   
© The Author(s) 2023

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