Exosomal circRNA: emerging insights into cancer progression and clinical application potential

Journal of Hematology & Oncology

Review

Yongmin Yan¹  Fan Zhang²  Wenrong Xu²  Jiajia Jiang²  Hui Qian³ 

[1] Aoyang Institute of Cancer, Affiliated Aoyang Hospital of Jiangsu University, 279 Jingang Road, 215600, Zhangjiagang, Suzhou, Jiangsu, People’s Republic of China;Department of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, No. 2 North Yongning Road, 213017, Changzhou, Jiangsu, People’s Republic of China;Aoyang Institute of Cancer, Affiliated Aoyang Hospital of Jiangsu University, 279 Jingang Road, 215600, Zhangjiagang, Suzhou, Jiangsu, People’s Republic of China;Zhenjiang Key Laboratory of High Technology Research on sEVs Foundation and Transformation Application, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, People’s Republic of China;Zhenjiang Key Laboratory of High Technology Research on sEVs Foundation and Transformation Application, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, People’s Republic of China;

关键词: Exosome;    circRNA;    Tumor immunity;    Tumor metabolism;    Biomarker;    Cancer therapy;   

DOI  :  10.1186/s13045-023-01452-2

 received in 2023-02-23, accepted in 2023-05-10,  发布年份 2023

来源: Springer

【 摘 要 】

Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and other components, thereby regulating critical aspects of cancer progression including immune escape, tumor angiogenesis, metabolism, drug resistance, proliferation and metastasis. Interestingly, microenvironment cells have new findings in influencing tumor progression and immune escape mediated by the release of exosomal circRNA. Given the intrinsic stability, abundance, and broad distribution of exosomal circRNAs, they represent excellent diagnostic and prognostic biomarkers for liquid biopsy. Moreover, artificially synthesized circRNAs may open up new possibilities for cancer therapy, potentially bolstered by nanoparticles or plant exosome delivery strategies. In this review, we summarize the functions and underlying mechanisms of tumor cell and non-tumor cell-derived exosomal circRNAs in cancer progression, with a special focus on their roles in tumor immunity and metabolism. Finally, we examine the potential application of exosomal circRNAs as diagnostic biomarkers and therapeutic targets, highlighting their promise for clinical use.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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