Spatiotemporally controlled drug delivery via photothermally driven conformational change of self-integrated plasmonic hybrid nanogels

Journal of Nanobiotechnology

Research

Seungki Lee¹  Doyun Kim¹  Jieun You¹  Hakchun Kim¹  Inhee Choi²  Subeen Kim³  Jihwan Song³  Ji Soo Kim⁴  Jungwon Park⁵ 

[1] Department of Life Science, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-Gu, 02504, Seoul, Republic of Korea;Department of Life Science, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-Gu, 02504, Seoul, Republic of Korea;Department of Applied Chemistry, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-Gu, 02504, Seoul, Republic of Korea;Department of Mechanical Engineering, Hanbat National University, 125 Dongseodaero, Yuseong-Gu, 34158, Daejeon, Republic of Korea;School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, 1 Gwanakro, Gwanak-Gu, 08826, Seoul, Republic of Korea;School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, 1 Gwanakro, Gwanak-Gu, 08826, Seoul, Republic of Korea;Center for Nanoparticle Research, Institute for Basic Science (IBS), 08826, Seoul, Republic of Korea;

关键词: Hybrid nanogel;    Light-responsive delivery;    Photothermal conversion;    Plasmonic nanoparticles;   

DOI  :  10.1186/s12951-023-01935-x

 received in 2023-02-28, accepted in 2023-05-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSpatiotemporal regulation is one of the major considerations for developing a controlled and targeted drug delivery system to treat diseases efficiently. Light-responsive plasmonic nanostructures take advantage due to their tunable optical and photothermal properties by changing size, shape, and spatial arrangement.ResultsIn this study, self-integrated plasmonic hybrid nanogels (PHNs) are developed for spatiotemporally controllable drug delivery through light-driven conformational change and photothermally-boosted endosomal escape. PHNs are easily synthesized through the simultaneous integration of gold nanoparticles (GNPs), thermo-responsive poly (N-isopropyl acrylamide), and linker molecules during polymerization. Wave-optic simulations reveal that the size of the PHNs and the density of the integrated GNPs are crucial factors in modulating photothermal conversion. Several linkers with varying molecular weights are inserted for the optimal PHNs, and the alginate-linked PHN (A-PHN) achieves more than twofold enhanced heat conversion compared with others. Since light-mediated conformational changes occur transiently, drug delivery is achieved in a spatiotemporally controlled manner. Furthermore, light-induced heat generation from cellular internalized A-PHNs enables pinpoint cytosolic delivery through the endosomal rupture. Finally, the deeper penetration for the enhanced delivery efficiency by A-PHNs is validated using multicellular spheroid.ConclusionThis study offers a strategy for synthesizing light-responsive nanocarriers and an in-depth understanding of light-modulated site-specific drug delivery.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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