Journal of Nanobiotechnology | |
Regulating electron transportation by tungsten oxide nanocapacitors for enhanced radiation therapy | |
Research | |
Wenbo Bu1  Ya Wang1  Yanyan Liu1  Han Wang2  Dalong Ni2  Hongbo Gao3  Qianwen Shen3  Li Sun3  Xiangpeng Zheng3  Libo Zhang4  Jinjin Li5  | |
[1] Department of Material Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 200433, Shanghai, China;Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China;Department of Radiation Oncology, Shanghai Huadong Hospital, Fudan University, 200040, Shanghai, China;Department of Radiology, The First Affiliated Hospital of Soochow University, 215006, Suzhou, China;Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 200062, Shanghai, China; | |
关键词: Tungsten oxide; Cancer; Radiotherapy; Nanotechnology; Pseudocapacitor; | |
DOI : 10.1186/s12951-023-01962-8 | |
received in 2023-05-06, accepted in 2023-06-17, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
In the process of radiation therapy (RT), the cytotoxic effects of excited electrons generated from water radiolysis tend to be underestimated due to multiple biochemical factors, particularly the recombination between electrons and hydroxyl radicals (·OH). To take better advantage of radiolytic electrons, we constructed WO3 nanocapacitors that reversibly charge and discharge electrons to regulate electron transportation and utilization. During radiolysis, WO3 nanocapacitors could contain the generated electrons that block electron-·OH recombination and contribute to the yield of ·OH at a high level. These contained electrons could be discharged from WO3 nanocapacitors after radiolysis, resulting in the consumption of cytosolic NAD+ and impairment of NAD+-dependent DNA repair. Overall, this strategy of nanocapacitor-based radiosensitization improves the radiotherapeutic effects by increasing the utilization of radiolytic electrons and ·OH, warranting further validation in multiple tumour models and preclinical experiments.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
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RO202309076752837ZK.pdf | 2093KB | download | |
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MediaObjects/13690_2023_1116_MOESM2_ESM.docx | 50KB | Other | download |
40517_2023_259_Article_IEq90.gif | 1KB | Image | download |
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