Structural characterizations and α-glucosidase inhibitory activities of four Lepidium meyenii polysaccharides with different molecular weights

Natural Products and Bioprospecting

Original Article

Ming-Hua Qiu¹  Li-Wu Lin¹  Zhou-Wei Wu¹  Xing-Rong Peng¹  Abdulbaset Al-Romaima¹  Luan Wen¹ 

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, Yunnan, People’s Republic of China;University of Chinese Academy of Sciences, 100049, Beijing, People’s Republic of China;

关键词: Lepidium meyenii;    Polysaccharide;    Molecular weight;    Structural characterization;    α;   

DOI  :  10.1007/s13659-023-00384-1

 received in 2023-05-05, accepted in 2023-05-30,  发布年份 2023

来源: Springer

【 摘 要 】

Four polysaccharides (MCPa, MCPb, MCPc, MCPd) were obtained from Lepidium meyenii Walp. Their structures were characterized by chemical and instrumental methods including total sugar, uronic acid and protein content determination, UV, IR and NMR spectroscopy, as well as monosaccharide composition determination and methylation analyses. Four polysaccharides were a group of glucans with different molecular weights ranging from 3.12 to 14.4 kDa, and shared a similar backbone chain consisting of (1→4)-glucose linkages with branches attached to C-3 and C-6. Furthermore, bioactivity assay showed that MCPs had concentration-dependent inhibitory activity on α-glucosidase. MCPb (Mw = 10.1 kDa) and MCPc (Mw = 5.62 kDa) with moderate molecular weights exhibited higher inhibitory activity compared with MCPa and MCPd.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 2