Predictors of participant retention in a community-based HIV prevention cohort: perspectives from the HPTN 071 (PopART) study

Trials

Research

Lungiswa Nkonki¹  Sarah Fidler²  Sian Floyd³  Richard Hayes³  Rosa Sloot⁴  Nomtha Bell-Mandla⁴  Nozizwe Makola⁴  Peter Bock⁴  Ayana Moore⁵  Deeksha Sharma⁶  Deborah Donnell⁶  Ethan Wilson⁶  Estelle Piwowar-Manning⁷  Justin Bwalya⁸  Musonda Simwinga⁸  Helen Ayles⁹  Ab Schaap^1,10 

[1] Department of Global Health, Division of Health Systems and Public Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Department of Infectious Disease Epidemiology, Imperial College London, London, UK;Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa;FHI360, FHI360, Durham, NC, USA;Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Johns Hopkins University School of Medicine, Baltimore, USA;Zambia AIDS Related Tuberculosis Project, University of Zambia, Lusaka, Zambia;Zambia AIDS Related Tuberculosis Project, University of Zambia, Lusaka, Zambia;Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK;Zambia AIDS Related Tuberculosis Project, University of Zambia, Lusaka, Zambia;Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK;

关键词: Community randomized trial;    HIV;    Longitudinal research;    Retention;    Gender;    Age;    Study precision;   

DOI  :  10.1186/s13063-023-07404-y

 received in 2022-07-27, accepted in 2023-05-23,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionIn 2021, there were 38.4 million people living with HIV (PLHIV) globally, of which 20.6 million (54%) were living in Eastern and Southern Africa. Longitudinal studies, inclusive of community randomized trials (CRTs), provide critical evidence to guide a broad range of health care interventions including HIV prevention. In this study, we have used an individual-level cohort study design to evaluate the association between sex and other baseline characteristics and participant retention in the HPTN 071 (PopART) trial in Zambia and South Africa.MethodsHPTN 071 (PopART) was a community randomized trial (CRT) conducted from 2013 to 2018, in 21 communities. The primary outcome was measured in a randomly selected population cohort (PC), followed up over 3 to 4 years at annual rounds. PC retention was defined as completion of an annual follow-up questionnaire. Baseline characteristics were described by study arm and Poisson regression analyses used to measure the association between baseline factors and retention. In addition, we present a description of researcher-documented reasons for study withdrawal by PC participants.ResultsOf the 38,474 participants enrolled during the first round of the trial (PC0), most were women (27,139, 71%) and 73% completed at least one follow-up visit. Retention was lower in men (adj RR: 0.90; 95% CI: 0.88, 0.91) and higher among older participants (adj RR: 1.23; 95% CI 1.20, 1.26) when comparing ages 35–44 to 18–24 years. Retention was higher among individuals with high socioeconomic status (SES) (adj RR 1.16; 95% CI 1.14, 1.19) and medium SES (adj RR 1.12; 95% CI 1.09, 1.14) compared to low SES. The most common reasons for study withdrawal were study refusal (23%) and relocation outside the CRT catchment area (66%).ConclusionDespite challenges, satisfactory retention outcomes were achieved in PopART with limited variability across study arms. In keeping with other studies, younger age, male sex, and lower SES were associated with lower levels of retention. Relocation outside of catchment area was the most common reason for non-retention in this CRT.

【 授权许可】

CC BY   
© The Author(s) 2023