Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis

BMC Psychiatry

Research

Jianglin Ma¹  Bing Chen²  Kangyu Jin²  Jing Lu³  Qin Zhang⁴  Yuyan Zhang⁵  Jinghui Zhang⁵  Jingyi Dong⁵ 

[1] Department of Pediatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, China;First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China;School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China;

关键词: Probiotics;    Prebiotics;    Synbiotics;    Depression;    Gut microbiota;   

DOI  :  10.1186/s12888-023-04963-x

 received in 2023-03-06, accepted in 2023-06-15,  发布年份 2023

来源: Springer

【 摘 要 】

Accumulating studies have shown the effects of gut microbiota management tools in improving depression. We conducted a meta-analysis to evaluate the effects of prebiotics, probiotics, and synbiotics on patients with depression. We searched six databases up to July 2022. In total, 13 randomized controlled trials (RCTs) with 786 participants were included. The overall results demonstrated that patients who received prebiotics, probiotics or synbiotics had significantly improved symptoms of depression compared with those in the placebo group. However, subgroup analysis only confirmed the significant antidepressant effects of agents that contained probiotics. In addition, patients with mild or moderate depression could both benefit from the treatment. Studies with a lower proportion of females reported stronger effects for alleviating depressive symptoms. In conclusion, agents that manipulate gut microbiota might improve mild-to-moderate depression. It is necessary to further investigate the benefits of prebiotic, probiotic and synbiotic treatments relative to antidepressants and follow up with individuals over a longer time before these therapies are implemented in clinical practice.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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