Association between symptoms of severe periodontitis and post-bronchodilator lung function: results from the China pulmonary health study

BMC Pulmonary Medicine

Research

Yingxiang Lin¹  Kewu Huang¹  Lirong Liang²  Xiaozhe Han³  Ting Yang⁴  Chen Wang⁵  Xuan Zhou⁶  Zuomin Wang⁶  Zhiqiang Liu⁶ 

[1] Beijing Institute of Respiratory Medicine, Beijing, China;Department of Pulmonary and Critical Care Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Chao-Yang Hospital, Beijing, China;Department of Clinical Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China;Beijing Institute of Respiratory Medicine, Beijing, China;Department of Oral Science and Translational Research, Nova Southeastern University College of Dental Medicine, Florida, USA;Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, 2 Yinghuayuan Dongjie, Chaoyang District, 100029, Beijing, China;National Clinical Research Center for Respiratory Diseases, Beijing, China;Institute of Respiratory Medicine, Peking Union Medical College, Beijing, China;Department of Respiratory Medicine, Capital Medical University, Beijing, China;Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, 2 Yinghuayuan Dongjie, Chaoyang District, 100029, Beijing, China;National Clinical Research Center for Respiratory Diseases, Beijing, China;Institute of Respiratory Medicine, Peking Union Medical College, Beijing, China;Department of Respiratory Medicine, Capital Medical University, Beijing, China;WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China;Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongti South Road, Chaoyang District, 100020, Beijing, China;

关键词: Lung function;    Periodontitis;    COPD;    Cross-sectional;    Epidemiology;    Risk factor;   

DOI  :  10.1186/s12890-023-02485-6

 received in 2022-10-21, accepted in 2023-05-17,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe association between periodontitis and post-bronchodilator lung function is unclear. We aimed to determine the associations between symptoms of severe periodontitis (SSP) and post-bronchodilator lung function in the Chinese population.MethodsA cross-sectional study (China Pulmonary Health study) was conducted from 2012 to 2015 in a large Chinese nationally representative sample of 49,202 participants aged 20–89 years. Data on demographic characteristics and periodontal symptoms of participants were collected by questionnaire. Participants who had at least one of the two severe symptoms (tooth mobility and natural tooth loss) in the past year were defined to have SSP, which was set as one variable for analyses. Post-bronchodilator lung function data including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were collected by spirometry.ResultsThe values of post-FEV1, post-FVC and post-FEV1/FVC of the participants with SSP were all significantly lower than the participants without SSP (all p < 0.001). SSP were significantly associated with post-FEV1/FVC < 0.7 (p < 0.001). In the multiple regression analyses, SSP were still negatively associated with post-FEV1(b = -0.04, 95%CI (-0.05 -0.03), p < 0.001), post-FEV1/FVC (b = -0.45, 95%CI (-0.63, -0.28), p < 0.001) and significantly associated with post-FEV1/FVC < 0.7 (OR = 1.08, 95%CI 1.01—1.16, p = 0.03) after full adjustment for potential confounders.ConclusionsOur data suggest that SSP were negatively associated with post-bronchodilator lung function in the Chinese population. Longitudinal cohort studies are needed to confirm these associations in the future.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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