Recurrent bilateral adrenal infarction with myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U): a case report

BMC Endocrine Disorders

Case Report

Yosuke Masamoto¹  Megumi Yasunaga¹  Hiroaki Maki¹  Kensuke Matsuda¹  Akira Honda¹  Mineo Kurokawa²  Maki Takeuchi³  Junichiro Sato³  Noriko Makita³  Masaomi Nangaku³  Katsunori Manaka³  Nobuaki Ito³  Hirofumi Horikoshi³  Megumi Fujita³  Yui Asatsuma³  Yoshitomo Hoshino³ 

[1] Department of Hematology and Oncology, The University of Tokyo Hospital, Tokyo, Japan;Department of Hematology and Oncology, The University of Tokyo Hospital, Tokyo, Japan;Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan;Division of Nephrology and Endocrinology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-Ku, Tokyo, Japan;

关键词: Bilateral adrenal infarction;    Recurrent adrenal infarction;    Myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U);    Primary adrenal insufficiency;    Adrenocortical function;    Case report;   

DOI  :  10.1186/s12902-023-01384-5

 received in 2022-08-11, accepted in 2023-05-30,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundBilateral adrenal infarction is rare and only a small number of cases have been reported so far. Adrenal infarction is usually caused by thrombophilia or a hypercoagulable state, such as antiphospholipid antibody syndrome, pregnancy, and coronavirus disease 2019. However, adrenal infarction with myelodysplastic/myeloproliferative neoplasm (MDS/MPN) has not been reported.Case presentationAn 81-year-old man with a sudden severe bilateral backache presented to our hospital. Contrast-enhanced computed tomography (CT) led to the diagnosis of bilateral adrenal infarction. Previously reported causes of adrenal infarction were all excluded and a diagnosis of MDS/MPN-unclassifiable (MDS/MPN-U) was reached, which was considered to be attributed to adrenal infarction. He developed a relapse of bilateral adrenal infarction, and aspirin administration was initiated. Partial primary adrenal insufficiency was suspected as the serum adrenocorticotropic hormone level was persistently high after the second bilateral adrenal infarction.ConclusionThis is the first case of bilateral adrenal infarction with MDS/MPN-U encountered. MDS/MPN has the clinical characteristics of MPN. It is reasonable to assume that MDS/MPN-U may have influenced bilateral adrenal infarction development, considering the absence of thrombosis history and a current comorbid hypercoagulable disease. This is also the first case of recurrent bilateral adrenal infarction. It is important to carefully investigate the underlying cause of adrenal infarction once adrenal infarction is diagnosed, as well as to assess adrenocortical function.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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