Acute acrylamide poisoning with severe symptoms in a short time: a case report

International Journal of Emergency Medicine

Case Report

Yoshito Kamijo¹  Tomoki Hanazawa¹  Rie Yamamoto²  Takayuki Yasuoka²  Keiji Sakurai³  Junya Matsushima³  Kazuki Akieda³  Hideaki Kanazashi³  Youhei Tsubouchi³ 

[1] Clinical Toxicology Center, Saitama Medical University Hospital, 38 Morohongo, Moroyama-machi, Iruma-Gun, Saitama, Japan;Department of Emergency and Critical Medicine, Tokai University Hospital, 143 Shimokasuya, 259-1193, Isehara-shi, Kanagawa, Japan;Emergency Department, SUBARU Health Insurance Society, Ota Memorial Hospital, Oshimacho, Ota, Gunma, Japan;

关键词: Acute acrylamide poisoning;    Dose;    Dose rate;    Severity;   

DOI  :  10.1186/s12245-023-00514-z

 received in 2023-03-02, accepted in 2023-06-12,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAcrylamide poisoning is often reported as chronic poisoning presenting with peripheral neuropathy or carcinogenic action due to long-term exposure to low concentrations. However, there have been few reports of acute poisoning due to oral ingestion of acrylamide, where the symptoms appear a few hours after ingestion. Here, we report a case of acute acrylamide poisoning where a high concentration was ingested in a short time, resulting in a fatal outcome due to the rapid course of events.Case presentationThe patient was an adolescent female who ingested 150 ml (148 g) of acrylamide with suicidal intent. A disorder of consciousness was observed when the emergency medical team arrived 36 min later. An hour later, tracheal intubation and intravenous access were performed at a hospital, and 2 h after that, she was transported to our hospital. After she arrived at the hospital, circulatory dynamics could not be maintained despite vasopressor and colloid osmotic infusion, and hemodialysis could not be introduced. Subsequently, cardiopulmonary arrest occurred, and the patient passed away 7 h after ingestion.In the present case, severe symptoms appeared shortly after acrylamide ingestion, unlike other reported cases. In previous report summarizing animal studies, there was a relationship among the symptoms of acute poisoning, the dose, and onset time. The data from this case were compared to those from previous reports, and we were able to predict the early appearance of severe symptoms based on this comparison.ConclusionThe severity of acute acrylamide poisoning by oral ingestion was primarily dependent on the amount and rate of ingestion.

【 授权许可】

CC BY   
© The Author(s) 2023