Prediction of risk of ischemic heart disease in first-diagnosed systemic lupus erythematosus patients in taiwan: is air pollution exposure a risk factor?

BMC Rheumatology

Research

Wen-Chao Ho¹  Pei-Yun Chen²  Chao-Tung Yang³  Yun-Mei Lee⁴  Yu-Tse Tsan⁵  Shu-Hua Lu⁶  Li-Li Chen⁶ 

[1] Departmant of public Health, China Medical University, Taichung, Taiwan;Departmant of public Health, China Medical University, Taichung, Taiwan;Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan;Department of Computer Science, Tunghai University, Taichung, Taiwan;Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, New Taipei City, Taiwan;Division of Occupational Medicine, Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;Department of Occupational Safety and Health Office, Taichung Veterans General Hospital, Taichung, Taiwan;School of Medicine, Chung Shan Medical University, Taichung, Taiwan;School of Nursing, China Medical University, Taichung, Taiwan;Department of Nursing, China Medical University Hospital, Taichung, Taiwan;

关键词: Ischemic heart disease;    Systemic lupus erythematosus;    Air pollution;    Hazard;   

DOI  :  10.1186/s41927-023-00337-8

 received in 2022-08-01, accepted in 2023-05-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAir pollution is a key public health factor with the capacity to induce diseases. The risk of ischemia heart disease (IHD) in those suffering from systemic lupus erythematosus (SLE) from air pollution exposure is ambiguous. This study aimed to: (1) determine the hazard ratio (HR) of IHD after the first-diagnosed SLE and (2) examine the effects of air pollution exposure on IHD in SLE for 12 years.MethodsThis is a retrospective cohort study. Taiwan’s National Health Insurance Research Database and Taiwan Air Quality Monitoring data were used in the study. Cases first diagnosed with SLE in 2006 cases without IHD were recruited as the SLE group. We randomly selected an additional sex-matched non-SLE cohort, four times the size of the SLE cohort, as the control group. Air pollution indices by residence city per period were calculated as the exposure. Life tables and Cox proportional risk models of time-dependent covariance were used in the research.ResultsThis study identified patients for the SLE group (n = 4,842) and the control group (n = 19,368) in 2006. By the end of 2018, the risk of IHD was significantly higher in the SLE group than in the control group, and risks peaked between the 6th and 9th year. The HR of incidence IHD in the SLE group was 2.42 times that of the control group. Significant correlations with risk of developing IHD were noted for sex, age, CO, NO2, PM10, and PM2.5, of which PM10 exposure had the highest risk of IHD incidence.ConclusionsSubjects with SLE were at a higher risk of IHD, especially those in the 6th to 9th year after SLE diagnosis. The advanced cardiac health examinations and health education plan should be recommended for SLE patients before the 6th year after SLE diagnosed.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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