BOHEMIA a cluster randomized trial to assess the impact of an endectocide-based one health approach to malaria in Mozambique: baseline demographics and key malaria indicators

Malaria Journal

Research

Edgar Jamisse¹  Eldo Elobolobo¹  Charfudin Sacoor¹  Saimado Imputiua¹  Humberto Munguambe¹  Francisco Saute¹  Kexin Xie²  Xinwei Deng²  Paula Ruiz-Castillo³  Aina Casellas³  Felisbela Materrula³  Julia Montaña⁴  Patricia Nicolas⁴  Carlos Chaccour⁵  Regina Rabinovich⁶  Achla Marathe⁷ 

[1] Centro de Investigaçao em Saúde de Manhiça, Manhiça, Mozambique;Department of Statistics, Virginia Tech, Blacksburg, VA, USA;ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain;ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain;Centro de Investigaçao em Saúde de Manhiça, Manhiça, Mozambique;ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain;Ciberinfec, Madrid, Spain;Universidad de Navarra, Pamplona, Spain;ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain;Harvard T.H. Chan School of Public Health, Boston, USA;Network Systems Science and Advanced Computing Division, Biocomplexity Institute, University of Virginia, Charlottesville, VA, USA;Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA;

关键词: Mozambique;    Mopeia;    BOHEMIA;    Demographic survey;    Mapping;    Long-lasting insecticidal nets;    Indoor residual spraying;    Population structure;    Malaria;   

DOI  :  10.1186/s12936-023-04605-3

 received in 2023-02-17, accepted in 2023-05-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMany geographical areas of sub-Saharan Africa, especially in rural settings, lack complete and up-to-date demographic data, posing a challenge for implementation and evaluation of public health interventions and carrying out large-scale health research. A demographic survey was completed in Mopeia district, located in the Zambezia province in Mozambique, to inform the Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) cluster randomized clinical trial, which tested ivermectin mass drug administration to humans and/or livestock as a potential novel strategy to decrease malaria transmission.MethodsThe demographic survey was a prospective descriptive study, which collected data of all the households in the district that accepted to participate. Households were mapped through geolocation and identified with a unique identification number. Basic demographic data of the household members was collected and each person received a permanent identification number for the study.Results25,550 households were mapped and underwent the demographic survey, and 131,818 individuals were registered in the district. The average household size was 5 members and 76.9% of households identified a male household head. Housing conditions are often substandard with low access to improved water systems and electricity. The reported coverage of malaria interventions was 71.1% for indoor residual spraying and 54.1% for universal coverage of long-lasting insecticidal nets. The median age of the population was 15 years old. There were 910 deaths in the previous 12 months reported, and 43.9% were of children less than 5 years of age.ConclusionsThe study showed that the district had good coverage of vector control tools against malaria but sub-optimal living conditions and poor access to basic services. The majority of households are led by males and Mopeia Sede/Cuacua is the most populated locality in the district. The population of Mopeia is young (< 15 years) and there is a high childhood mortality. The results of this survey were crucial as they provided the household and population profiles and allowed the design and implementation of the cluster randomized clinical trial.Trial registration NCT04966702.

【 授权许可】

CC BY   
© The Author(s) 2023

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