Control of the injection velocity of embolic agents in embolization treatment

BioMedical Engineering OnLine

Research

Jiasheng Li¹  Dongcheng Ren¹  Shijie Guo¹  Bo Zhou²  Baolei Guo³ 

[1] Academy for Engineering and Technology, Fudan University, 220 Handan Rd., Shanghai, China;Shanghai Engineering Research Center of AI & Robotics, 539 Handan Rd., 200433, Shanghai, China;Engineering Research Center of AI & Robotics, Ministry of Education, 539 Handan Rd., Shanghai, China;Department of Interventional Radiology, Fudan University Zhongshan Hospital, 180 Fenglin Rd., Shanghai, China;National Clinical Research Center for Interventional Medicine, 180 Fenglin Rd., Shanghai, China;Department of Vascular Surgery, Fudan University Zhongshan Hospital, 180 Fenglin Rd., 200032, Shanghai, China;National Clinical Research Center for Interventional Medicine, 180 Fenglin Rd., Shanghai, China;

关键词: Biofluid dynamics;    Embolization;    Interventional surgery;    Injection velocity;    Porous media;   

DOI  :  10.1186/s12938-023-01126-7

 received in 2022-10-31, accepted in 2023-06-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEmbolization is a common treatment method for tumor-targeting, anti-organ hyper-function, and hemostasis. However, the injection of embolic agents largely depends on the experiences of doctors, and doctors need to work in an X-ray environment that hurts their health. Even for a well-trained doctor, complications such as ectopic embolism caused by excessive embolic agents are always inevitable.ResultsThis paper established a flow control curve model for embolic injection based on local arterial pressure. The end-vessel network was simplified as a porous media. The hemodynamic changes at different injection velocities and embolization degrees were simulated and analyzed. Sponge, a typical porous medium, was used to simulate the blocking and accumulation of embolic agents by capillary networks in the in vitro experimental platform.ConclusionsThe simulation and experimental results show that the local arterial pressure is closely related to the critical injection velocity of the embolic agent reflux at a certain degree of embolization. The feasibility of this method for an automatic embolic injection system is discussed. It is concluded that the model of the flow control curve of embolic injection can effectively reduce the risk of ectopic embolism and shorten the time of embolic injection. The clinical application of this model is of great value in reducing radiation exposure and improving the success rate of interventional embolization.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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