Frailty in chronic myeloid leukemia: evidence from 2016–2018 Nationwide Inpatient Sample of the US

BMC Geriatrics

Research

Lin Huan-Tze¹  Tzeng Huey-En²  Lee Kuan-Der³  Liu Yun-Ru⁴ 

[1] Department of Internal Medicine, Division of Hematology and Oncology, Taipei Medical University Hospital, Taipei, Taiwan;Department of Internal Medicine, Division of Hematology and Oncology, Taipei Medical University Hospital, Taipei, Taiwan;Department of Medical Research, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4, 40705, Taichung City, Taiwan;Department of Medicine, Division of Hematology/Medical Oncology, Taichung Veterans General Hospital, Taichung City, Taiwan;Ph.D. Program for Cancer Molecular Biology and Drug Discovery, and Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan;Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan;Department of Medical Research, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4, 40705, Taichung City, Taiwan;Joint Biobank, Office of Human Research, Taipei Medical University, Taipei, Taiwan;

关键词: Frailty;    Chronic myeloid leukemia (CML);    In-hospital outcome;    Nationwide Inpatient Sample (NIS);   

DOI  :  10.1186/s12877-023-03962-7

 received in 2022-11-25, accepted in 2023-04-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundFrailty is a marker of poor prognosis in older adults with hematologic malignancies and contributes to the severe vulnerability of the aging population to adverse health outcomes. This study aimed to determine the association between frailty and outcomes in hospitalized patients with chronic myeloid leukemia (CML).MethodsThe International Classification of Diseases (ICD-10) identified data on hospitalized patients 20 years or older admitted with CML between 2016 and 2018 in the US National Inpatient Sample (NIS) database. The cohort was further divided into groups of patients with or without frailty. Logistic regression analysis was performed to determine associations between study variables and clinical outcomes. A stratified analysis of the association between frailty and in-hospital mortality by age group was also performed.ResultsA total of 13,849 hospitalized patients with CML were included, 49.6% of whom had frailty. The mean age of the patients was 65.1 years, and 7,619 (56.2%) of them were male. Frailty was associated with nearly 4 times the risk of in-hospital mortality, 3 times the risk of unfavorable discharge, 3 times the risk of prolonged LOS,, and significantly more in total hospital costs. In addition, frailty was associated with a significantly increased risk of in-hospital mortality in all age subgroups (< 40 years, 40–59 years, and > 60 years) compared with no frailty.ConclusionsFrailty strongly predicts poor clinical outcomes in US patients with CML.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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