Evaluation and correlation analysis of ocular surface disorders and quality of life in autoimmune rheumatic diseases: a cross-sectional study

BMC Ophthalmology

Research

Baihua Chen¹  Yuerong Ren¹  Yan He¹  Wen Shi¹  Huanmin Kang¹  Jianing Feng¹  Yingyi Liu¹  Jing Tian² 

[1] Department of Ophthalmology, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China;Hunan Clinical Research Center of Ophthalmic Disease, 410011, Changsha, Hunan, China;Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China;

关键词: Dry eye disease;    Autoimmune rheumatic diseases;    Ocular surface;    Quality of life;    Anxiety and depression;   

DOI  :  10.1186/s12886-023-02959-5

 received in 2023-03-05, accepted in 2023-05-04,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveThis cross-sectional study aimed to reveal the association between ocular surface disorders and psychological, physiological situations among autoimmune rheumatic patients.MethodsNinety autoimmune rheumatic patients (180 eyes) hospitalized in the Department of Rheumatology, The Second Xiangya Hospital, Central South University and 30 controls (60 eyes) were enrolled in the study. All participants were assessed for ocular surface disorders including dry eye disease (DED) by the Ocular Surface Disease Index (OSDI) for symptoms evaluation, and slim lamp examinations for tear break-up time (TBUT), meibomian gland secretion, symblepharon and corneal clarity, Schirmer I test, corneal fluorescein staining (CFS), lid-parallel conjunctival folds (LIPCOF). Systematic conditions were evaluated using the Short Form 36-Health Survey (SF-36) for health-related quality of life, Hospital Anxiety and Depression Scale (HADS) for anxiety and depression, Health Assessment Questionnaire-Disability Index (HAQ-DI) for difficulties in activities of daily living, and Pittsburgh Sleep Quality Index (PSQI) for sleep quality. Pearson and spearman’s analysis were conducted to examine the relationship between systematic conditions and ocular surface conditions.ResultsThe analyses were controlled for age and sex. 52.22% of eyes (94 in 180) of autoimmune rheumatic patients and 21.67% of eyes (13 in 60) of controls were diagnosed with DED. The autoimmune rheumatic patients showed significant higher OSDI score, fewer basal tear secretion, more severe CFS and conjunctivochalasis than controls. There were no statistically significant differences in TBUT, meibomian gland secretion, symblepharon, and corneal clarity between the two groups. For systematic conditions, autoimmune rheumatic patients had significantly lower SF-36 scores, higher anxiety scores, and HAQ-DI scores than controls. No statistically significant differences were detected in depression scores and PSQI between the two groups. Among autoimmune rheumatic patients, OSDI scores were moderately correlated with quality of life, anxiety, depression and sleep quality.ConclusionFactors including quality of life, anxiety, depression, and sleep quality are associated with ocular surface conditions, especially DED symptoms. Management of systemic conditions and psychotherapy should also be considered as part of the treatment among autoimmune rheumatic patients.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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