Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

BMC Medicine

Research Article

Ruth Travis¹  Jelena Bešević¹  Karl Smith-Byrne²  Rosario Tumino³  Domenico Palli⁴  Marie-Christine Boutron-Ruault⁵  Joseph A. Rothwell⁵  Gianluca Severi⁶  Sandra Colorado-Yohar⁷  Eva Ardanaz⁸  Anne Tjønneland⁹  Anne Kirstine Eriksen^1,10  Bas Bueno-de-Mesquita^1,11  Jerzy Adamski^1,12  Matthias B. Schulze^1,13  Kim Overvad^1,14  Christina C. Dahm^1,14  Linda Vidman^1,15  Bethany van Guelpen^1,16  Hector Keun^1,17  Fabrizio Pasanisi^1,18  Maria-José Sánchez^1,19  Therese Haugdahl Nøst^2,20  Torkjel M. Sandanger^2,20  Guri Skeie^2,20  Rudolf Kaaks^2,21  Verena Katzke^2,21  Fabian Eichelmann^2,22  Mazda Jenab^2,23  Marie Breeur^2,23  Niki Dimou^2,23  Neil Murphy^2,23  David Achaintre^2,23  Pietro Ferrari^2,23  Sabina Rinaldi^2,23  Inge Huybrechts^2,23  Roland Wedekind^2,23  Audrey Gicquiau^2,23  Augustin Scalbert^2,23  Vivian Viallon^2,23  Marc J. Gunter^2,24  Jeroen W. G. Derksen^2,25  Cornelia Prehn^2,26  Pilar Amiano^2,27  Marc Chadeau-Hyam^2,28  Amanda J. Cross^2,28  Kostas K. Tsilidis^2,29  Paolo Vineis^3,30  Raul Zamora-Ros^3,31 

[1] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK;Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK;International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008, Lyon, France;Cancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy;Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy;Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, F-94805, Villejuif, France;Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, F-94805, Villejuif, France;Department of Statistics, Computer Science, Applications “G. Parenti” University of Florence, Florence, Italy;Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain;Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain;Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia;Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain;Navarra Public Health Institute, Leyre 15, 31003, Pamplona, Spain;IdiSNA, Navarra Institute for Health Research, Pamplona, Spain;Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, DK-2100, Copenhagen, Denmark;Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, DK-2100, Copenhagen, Denmark;Department of Public Health, University of Copenhagen, Copenhagen, Denmark;Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720, Bilthoven, BA, The Netherlands;Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore, Singapore;Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany;Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia;Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany;Institute of Nutritional Science, University of Potsdam, Potsdam, Germany;Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus, Denmark;Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden;Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden;Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden;Department of Surgery & Cancer, Imperial College London, London, UK;Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy;Escuela Andaluza de Salud Pública (EASP), 18011, Granada, Spain;Instituto de Investigación Biosanitaria ibs. GRANADA, 18012, Granada, Spain;Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain;Department of Preventive Medicine and Public Health, University of Granada, 18071, Granada, Spain;Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, N-9037, Tromsø, Norway;German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany;German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany;Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany;International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008, Lyon, France;International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008, Lyon, France;School of Public Health, Imperial College London, London, UK;Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands;Metabolomics and Proteomics Core, Helmholtz Zentrum München, 85764, Neuherberg, Germany;Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain;Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain;Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain;School of Public Health, Imperial College London, London, UK;School of Public Health, Imperial College London, London, UK;Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece;School of Public Health, Imperial College London, London, UK;Italian Institute of Technology, Genova, Italy;Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain;

关键词: Colorectal cancer;    Amino acids;    Glutamine;    Histidine;   

DOI  :  10.1186/s12916-023-02739-4

 received in 2022-11-08, accepted in 2023-01-16,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAmino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.MethodsConcentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.ResultsHistidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded.ConclusionsHigher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain therole of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.

【 授权许可】

CC BY   
© The Author(s) 2023

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