Heterologous effect of influenza vaccination on molluscum contagiosum infection; a case report of siblings

BMC Pediatrics

Case Report

David E. Hrncir¹  Sofia M. Szari²  Thomas M. Beachkofsky³  Michelle L. Lawson⁴ 

[1] Defense Health Agency Public Health, Immunization Healthcare Division, San Antonio, TX, US;Department of Allergy and Immunology, SAUSHEC, San Antonio, TX, US;Department of Dermatology, James A. Haley Veterans Hospital, Tampa, FL, US;Division of Adolescent Medicine, Department of Pediatrics, San Antonio Uniformed Services Health Education Consortium (SAUSHEC), 3100 Schofield Road Fort Sam Houston, 78234, San Antonio, TX, US;

关键词: Case report;    Heterologous effect;    Influenza;    Vaccination;    Molluscum contagiosum;    Delayed-type hypersensitivity;   

DOI  :  10.1186/s12887-023-04019-9

 received in 2022-09-11, accepted in 2023-04-14,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMolluscum contagiosum virus (MCV) is a benign, common cutaneous infection predominantly affecting the younger pediatric population. Traditional treatments may be time consuming with variable efficacy. Time to spontaneous resolution is variable and treatment is often sought to shorten duration of infection, prevent further autoinoculation, prevent infectious spread to others and treat cosmetic intolerability.Case presentationWe present the case of two patients with complete, simultaneous clearance of their molluscum contagiosum infections after receiving a routine 2018 quadrivalent influenza vaccination. Neither patient has had recurrence of molluscum contagiosum or permanent scarring. We review trials of intralesional immunotherapy in treatment of cutaneous infections to theorize the mechanism of MCV infection clearance post influenza vaccination.ConclusionWe propose a delayed-type hypersensitivity reaction was induced as a heterologous effect of the influenza vaccination, similar to that seen in current immunotherapy treatments. This is the first reported case of MCV-directed immune reaction with infection clearance after influenza vaccination.

【 授权许可】

CC BY   
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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