Neuron-specific enolase in hypertension patients with acute ischemic stroke and its value forecasting long-term functional outcomes

BMC Geriatrics

Research

Yunlei Cai¹  Binbin Deng²  Lingfei Gao³  Chunyang Pang³  Jiali Xie⁴  Hangqi Zheng⁵  Haiqin Zhang⁵  Wanjun Zheng⁵ 

[1] Anyang District Hospital, Dengta Road, Beiguan District, Anyang City, Henan Province, PR China;Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;First Clinical College of Wenzhou Medical University, Wenzhou, China;Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai, PR China;First Clinical College of Wenzhou Medical University, Wenzhou, China;

关键词: Neuron specific enolase;    Functional outcome;    Nomogram;    Hypertension;    Stroke;   

DOI  :  10.1186/s12877-023-03986-z

 received in 2023-01-06, accepted in 2023-04-20,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundNeuron Specific Enolase (NSE), a neuro-biochemical protein marker, may correlate with the prognosis of stroke patients. Moreover, hypertension is the most common comorbidities in patients with acute ischemic stroke (AIS), and the relationship between NSE levels and long-term functional outcomes in such an increasingly large population is unclear. The aim of the study was to investigate the relationships mentioned above and optimize the prediction models.MethodsFrom 2018 to 2020, 1086 admissions for AIS were grouped as hypertension and non-hypertension, while hypertension group was randomly divided into development and validation cohorts for internal validation. The severity of the stroke was staged by National Institutes of Health Stroke Scale (NIHSS) score. Stroke prognosis after 1 year of follow up was documented by modified Rankin Scale (mRS) score.ResultsAnalysis revealed the following findings:(i) Serum NSE levels increased greatly in hypertension subjects with poor functional outcomes(p = 0.046). However, there was no association in non-hypertension individuals(p = 0.386). (ii) In addition to the conventional factors (age and NIHSS score), NSE (OR:1.241, 95% CI: 1.025–1.502) and prothrombin time were significantly related to the incidence of unfavorable outcomes. (iii)Based on the above four indicators, a novel nomogram was established to predict the prognosis of stoke in hypertension patients with the c-index values of 0.8851.ConclusionsOverall, high baseline NSE is associated with poor 1-year AIS outcomes in hypertension patients, suggesting NSE may be a potential prognostic and therapeutic target for stroke in hypertension patients.

【 授权许可】

CC BY   
© The Author(s) 2023

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