Ambient fine particulate matter and allergic symptoms in the middle-aged and elderly population: results from the PIFCOPD study

Respiratory Research

Research

Han Cao¹  Ruiying Wang²  Jing Li²  Jiping Liao³  Guangfa Wang³  Shanshan Wei³  Cheng Zhang³  Kunyao Yu³  Jian Sun⁴  Shujuan Jiang⁴  Beibei Song⁵  Xixin Yan⁵  Xiuhua Fu⁶  Rui Chen⁶  Lan He⁶  Liping Xie⁷  Weihua Jia⁷  Limin Zhao⁸  Tao Xue⁹  Hengyi Liu⁹  Lina Zhang^1,10  Guifang Zhang^1,11  Bifang Miao^1,12  Jianhong Xiao^1,12  Qian Ning^1,13  Xiaomin Dang^1,13  Bo Zhou^1,13  Shaochen Dong^1,14  Hua Qiao^1,14  Jinzhi Yin^1,15  Peng Gao^1,15  Wei Li^1,15  Lixia Dong^1,16  Mengyu Yin^1,16 

[1] Department of Biostatistics, Peking University First Hospital, Beijing, China;Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China;Department of Respiratory and Critical Care Medicine, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, 100034, Beijing, China;Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China;Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China;Hebei Key Laboratory of Respiratory Critical Care, Shijiazhuang, Hebei, China;Division of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China;General Hospital of Taiyuan Iron & Steel (Group) Co., LTD, Taiyuan, Shanxi, China;Henan Provincial People’s Hospital, Zhengzhou, Henan, China;Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China;Jining First People’s Hospital, Jining, Shandong, China;Jinyuan Community Health Service Center, Taiyuan, Shanxi, China;Mindong Hospital of Ningde City, Ningde, Fujian, China;Respiratory and Critical Care Medicine, Xi’an Jiaotong University Medical College First Affiliated Hospital, Xi’an, Shaanxi, China;The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China;The Second Hospital of Jilin University, Changchun, Jilin, China;Tianjin Medical University General Hospital, Tianjin, China;

关键词: Ambient fine particulate matter;    Allergic symptoms;    Short- and long-term exposure;   

DOI  :  10.1186/s12931-023-02433-2

 received in 2022-12-27, accepted in 2023-04-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe associations between short- and long-term exposure to ambient fine particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM2.5) and allergic symptoms in middle-aged and elderly populations remain unclear, particularly in China, where most cities have severe air pollution.MethodsParticipants (n = 10,142; age = 40–75 years) were recruited from ten regions in China from 2018 to 2021 for the Predictive Value of Inflammatory Biomarkers and Forced Expiratory Volume in 1 s (FEV1) for Chronic Obstructive Pulmonary Disease (PIFCOPD) study. Short-term (lag0 and lag0–7 day) and long-term (1-, 3- and 5-year) PM2.5 concentrations at residences were extracted from the air pollutant database known as Tracking Air Pollution (TAP) in China. Multivariate logistic regression models were used to estimate associations for short- and long-term PM2.5 exposure concentrations and long-term exposure models were additionally adjusted for short-term deviations.ResultsA 10 µg/m3 increase in PM2.5 on the day the allergic symptoms questionnaire was administered (lag0 day) was associated with higher odds of allergic nasal (1.09, 95% CI 1.05, 1.12) and eye symptoms (1.08, 95% CI 1.05, 1.11), worsening dyspnea caused by allergens (1.06, 95% CI 1.02, 1.10), and ≥ 2 allergic symptoms (1.07, 95% CI 1.03, 1.11), which was similar in the lag0–7 day concentrations. A 10 µg/m3 increase in the 1-year average PM2.5 concentration was associated with an increase of 23% for allergic nasal symptoms, 22% for eye symptoms, 20% for worsening dyspnea caused by allergens, and 21% for ≥ 2 allergic symptoms, similar to the 3- and 5-year average PM2.5 concentrations. These associations between long-term PM2.5 concentration and allergic symptoms were generally unchanged after adjustment for short-term deviations.ConclusionsShort- and long-term exposure to ambient PM2.5 was associated with an increased risk of allergic nasal and eye symptoms, worsening dyspnea caused by allergens, and ≥ 2 allergic symptoms.Trial registrationClinical trial ID: NCT03532893 (29 Mar 2018).

【 授权许可】

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© The Author(s) 2023