Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial

BMC Oral Health

Research

Erda Qorri¹  Gaetano Isola²  Antonio Scarano³  Elisabetta Ferrara⁴  Paola Dongiovanni⁵  Francesco Inchingolo⁶  Biagio Rapone⁶  Gianluca Martino Tartaglia⁷ 

[1] Dean Faculty of Medical Sciences, Albanian University, Bulevardi Zogu I, 1000, Tirana, Albania;Department of General Surgery and Medical Surgery Specialties, School of Dentistry, University of Catania, 95123, Catania, Italy;Department of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100, Chieti, Italy;Department of Medical, Oral and Biotechnological Sciences, University G. d’Annunzio, 66100, Chieti, Italy;General Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Pad. Granelli, via F Sforza 35, 20122, Milan, Italy;Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121, Bari, Italy;UOC Maxillo-Facial Surgery and Dentistry, Ospedale Maggiore Policlinico, Fondazione IRCCS Ca Granda, 20122, Milan, Italy;Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122, Milan, Italy;

关键词: Periodontitis;    Periodontal inflammation;    Type 2 diabetes;    Oxidative stress;    Antioxidant status, pro-oxidant status;   

DOI  :  10.1186/s12903-023-02985-1

 received in 2023-02-21, accepted in 2023-04-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundChronic inflammation and cumulative oxidative stress have been theorized as two common pathways of the interconnection between periodontitis and diabetes. Improvement in oxidizing status has been demonstrated in periodontal patients with diabetes treated with proper non-surgical periodontal treatment. In addition to periodontal treatment, Gaseous ozone therapy has been reported to possess anti-inflammatory properties and the ability to stimulate the endogenous antioxidant defence mechanism. To date, the antioxidant effect of gaseous ozone, in addition with periodontal treatment in diabetic patients, has been examined in only one study. The aim of this study was to determine the efficacy of gaseous ozone therapy as an alternative approach to supporting non-surgical periodontal therapy (NSPT), aimed at improving antioxidant machinery and interfering with ROS production on plasma levels in diabetic individuals diagnosed with moderate or severe periodontitis.MethodsOne hundred and eighty patients with periodontitis and type 2 diabetes mellitus were randomly assigned to receive non-surgical periodontal treatment (NSPT) plus gaseous ozone therapy (A) NSPT alone (B). Clinical and periodontal parameters -Bleeding on probing (BOP), Periodontal pocket depth (PPD), and Clinical attachment Level (CAL)- and plasma levels of oxidant-antioxidant (TOS- TAOS) levels, glutathione (GSH), and malondialdehyde (MDA) were recorded at baseline and at 3- (T1) and at 6-months (T2) after treatment.ResultsBoth treatments were efficacious in reducing clinical parameters. However, there were no significant differences regarding oxidative stress parameters in group A compared to group B.ConclusionsIn the present study, gaseous ozone therapy did not enhance the effect of periodontal treatment in reducing oxidative stress in plasma levels of periodontitis patients with type II diabetes.Trial registrationThe study was registered with ISRCTN1728169 (23/07/2022).

【 授权许可】

CC BY   
© The Author(s) 2023

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