Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma

Cancer Nanotechnology

Research

Raveena Nagareddy¹  In Kyu Park¹  Veena Vijayan¹  Ansuja Mathew Pullickal¹  Mee Sun Yoon²  Yong Yeon Jeong³  Subin Kim⁴  Reju George Thomas⁴ 

[1] Department of Biomedical Sciences, Chonnam National University Medical School and Hospital, Gwangju, Korea;Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea;Department of Radiology, Chonnam National University Medical School and Hwasun Hospital, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, 58128, Jeollanam-do, Republic of Korea;Department of Radiology, Chonnam National University Medical School and Hwasun Hospital, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, 58128, Jeollanam-do, Republic of Korea;Department of Biomedical Sciences, Chonnam National University Medical School and Hospital, Gwangju, Korea;

关键词: Liposome;    Manganese oxide;    Cancer;    Nanoparticle;    Hypoxia;   

DOI  :  10.1186/s12645-023-00182-x

 received in 2022-10-14, accepted in 2023-03-21,  发布年份 2023

来源: Springer

【 摘 要 】

Tumor hypoxia is an important factor for developing resistance to radiation therapy (RT) and presents a bleak prognosis in cancer patients undergoing treatment for RT resistant hepatocellular carcinoma. Here, we present the synthesis of liposome-coated Mn3O4 (MGN) nanoparticles (Lipo-MGN) and investigation of their therapeutic potential with RT utilizing a HepG2 cancer model. According to in vitro research, Lipo-MGN effectively produced oxygen in the presence of H2O2 and significantly reduced the expression of HIF-1 in human HepG2 cells that were under hypoxic conditions. Lipo-MGN reversed the radio-resistance brought on by hypoxia and increased cell damage. When Lipo-MGN and RT were administered together in a HepG2 xenograft mice model, the tumor growth was delayed more than with RT alone. As determined by MR imaging, liposome-MGN also exhibited T1 contrast enhancement in tumor. According to these findings, Lipo-MGNs may increase the impact of RT by focusing tumor hypoxia. Hypoxic, radioresistant HepG2 cancer may be treated with Lipo-MGN in clinical studies.

【 授权许可】

CC BY   
© The Author(s) 2023

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