New opportunities for RGD-engineered metal nanoparticles in cancer

Molecular Cancer

Review

Mohammed A.S. Abourehab¹  Jyoti Chandra²  Prashant Kesharwani³  Neelima Gupta⁴  Zhe-Sheng Chen⁵  Wei Qin⁶  Hui-Ling Cao⁶ 

[1]Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, 21955, Makkah, Saudi Arabia

[2]Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, 110062, New Delhi, India

[3]Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, 110062, New Delhi, India

[4]Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical science, Chennai, India

[5]Dr. Harisingh Gour Vishwavidyalaya (A Central University), 470003, Sagar, Madhya Pradesh, India

[6]Institute for Biotechnology, College of Pharmacy and Health Sciences, St. John’s University, 11439, Queens, New York, USA

[7]Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, College of Pharmacy, Xi’an Medical University, 710021, Xi’an, China

关键词: Cancer imaging;    cancer;    Metal nanoparticles;    RGD;    Integrin;    Drug targeting;   

DOI  :  10.1186/s12943-023-01784-0

 received in 2023-03-13, accepted in 2023-04-26,  发布年份 2023

来源: Springer

【 摘 要 】

The advent of nanotechnology has opened new possibilities for bioimaging. Metal nanoparticles (such as gold, silver, iron, copper, etc.) hold tremendous potential and offer enormous opportunities for imaging and diagnostics due to their broad optical characteristics, ease of manufacturing technique, and simple surface modification. The arginine-glycine-aspartate (RGD) peptide is a three-amino acid sequence that seems to have a considerably greater ability to adhere to integrin adhesion molecules that exclusively express on tumour cells. RGD peptides act as the efficient tailoring ligand with a variety of benefits including non-toxicity, greater precision, rapid clearance, etc. This review focuses on the possibility of non-invasive cancer imaging using metal nanoparticles with RGD assistance.Graphical abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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