Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity

Natural Products and Bioprospecting

Original Article

Hong-Ping He¹  Ke-Pu Huang²  Xiao-Jiang Hao³  Lian Yang³  Li-Li Xu³  Yin-Ling Wei³  Yu Zhang³  Sheng Li³ 

[1] School of Chinese Materia Medica, Yunnan University of Chinese Medicine, 650500, Kunming, People’s Republic of China;School of Chinese Materia Medica, Yunnan University of Chinese Medicine, 650500, Kunming, People’s Republic of China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, People’s Republic of China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, People’s Republic of China;

关键词: Uncaria rhynchophylla;    Monoterpene indole alkaloids;    Uncarialines A-E;    Anticoagulant activity;   

DOI  :  10.1007/s13659-023-00377-0

 received in 2023-03-09, accepted in 2023-04-03,  发布年份 2023

来源: Springer

【 摘 要 】

Uncarialines A-E (1–5), five undescribed monoterpene indole alkaloids, together with five known analogues were obtained from the stems of Uncaria rhynchophylla. Alkaloids 1–3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system, while 4 and 5 possessed a rare rearranged scaffold originated from corynantheine-type alkaloids with C-2/C-7 oxidation. Their structures were characterized by a comprehensive analysis of MS, NMR, and ECD. Their effects on blood clotting times of human plasma were evaluated and alkaloid 5 had a slight prolongation effect on both thrombin time and activated partial thromboplastin time (p < 0.001).Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023. corrected publication 2023

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