Feasibility of fine needle aspiration for diagnosis of b-cell lymphoma of the thyroid: a case series and review of the literature

Diagnostic Pathology

Case Report

Alexander D. Karabachev¹  Allison L. Ciolino²  Mirabelle B. Sajisevi³  William J. Brundage³ 

[1] Department of Otolaryngology, University of Cincinnati Medical Center, Cincinnati, OH, USA;Robert Larner College of Medicine, University of Vermont, Burlington, VT, USA;Robert Larner College of Medicine, University of Vermont, Burlington, VT, USA;Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT, USA;Robert Larner College of Medicine, University of Vermont, Burlington, VT, USA;Department of Surgery, Division of Otolaryngology, University of Vermont Medical Center, Burlington, VT, USA;

关键词: Pathology;    Thyroid cancer-clinical;    Thyroid lymphoma;    Fine needle aspiration;    Cell block;    Diagnosis;   

DOI  :  10.1186/s13000-023-01346-4

 received in 2022-11-09, accepted in 2023-04-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPrimary thyroid lymphoma (PTL) is a rare cancer accounting for approximately 5% of thyroid malignancies. Historically, incisional biopsy has been the gold standard for definitive diagnosis of PTL, however, the use of cell block as an adjunct to fine needle aspiration (FNA) provides a high sensitivity and specificity for diagnosis and classification.MethodsThree patients presented with a symptomatic enlarging thyroid mass. Patient 1 underwent incisional biopsy under general anesthesia, Patient 2 underwent core needle biopsy to avoid high risk intubation, and Patient 3 underwent fine needle aspiration alone with the use of cell block.ResultsAll patients were diagnosed with a fully classified non-Hodgkin’s lymphoma using immunohistochemistry, flow cytometry, and fluorescence in situ hybridization (FISH) analysis.ConclusionsFNA for diagnosis of some subtypes of PTL is feasible and preferred in cases that are particularly high risk for general anesthesia. This minimally invasive technique is safe and cost effective as it avoids expenses associated with operative intervention.

【 授权许可】

CC BY   
© The Author(s) 2023

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