Liver-specific metastases as an independent prognostic factor in cancer patients receiving hospice care in hospital

BMC Palliative Care

Research

Chih-Hung Lee¹  Kun-Siang Huang²  Chia-Pei Chou²  Bo-Lin Pan²  Yun-Hwa Huang²  Chao-Tung Chen² 

[1] Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;Chang Gung University College of Medicine, Taoyuan, Taiwan;Institute of Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;National Sun Yat-Sen University College of Medicine, Kaohsiung, Taiwan;Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;

关键词: Hospice;    Survival;    Liver metastasis;    Palliative;    Enteral nutrition;   

DOI  :  10.1186/s12904-023-01180-x

 received in 2022-09-08, accepted in 2023-05-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSurvival prediction is important in cancer patients receiving hospice care. Palliative prognostic index (PPI) and palliative prognostic (PaP) scores have been used to predict survival in cancer patients. However, cancer primary site with metastatic status, enteral feeding tubes, Foley catheter, tracheostomy, and treatment interventions are not considered in aforementioned tools. The study aimed to investigate the cancer features and potential clinical factors other than PPI and PaP to predict patient survival.MethodsWe conducted a retrospective study for cancer patients admitted to a hospice ward between January 2021 and December 2021. We examined the correlation of PPI and PaP scores with survival time since hospice ward admission. Multiple linear regression was used to test the potential clinical factors other than PPI and PaP for predicting survival.ResultsA total of 160 patients were enrolled. The correlation coefficients for PPI and PaP scores with survival time were -0.305 and -0.352 (both p < 0.001), but the predictabilities were only marginal at 0.087 and 0.118, respectively. In multiple regression, liver metastasis was an independent poor prognostic factor as adjusted by PPI (β = -8.495, p = 0.013) or PaP score (β = -7.139, p = 0.034), while feeding gastrostomy or jejunostomy were found to prolong survival as adjusted by PPI (β = 24.461, p < 0.001) or PaP score (β = 27.419, p < 0.001).ConclusionsAssociation between PPI and PaP with patient survival in cancer patients at their terminal stages is low. The presence of liver metastases is a poor survival factor independent of PPI and PaP score.

【 授权许可】

CC BY   
© The Author(s) 2023

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