Dysphagia is closely related to frailty in mild-to-moderate Alzheimer’s disease

BMC Geriatrics

Research

Serdar Ceylan¹  Süheyla Çöteli¹  Pelin Ünsal¹  Meltem Gülhan Halil¹  Arzu Okyar Baş¹  Merve Güner¹  Çağatay Çavuşoğlu¹  Burcu Balam Doğu¹  Mustafa Cankurtaran¹  Zeynep Kahyaoğlu¹  Cemile Özsürekci¹ 

[1] Faculty of Medicine, Department of Internal Medicine, Division of Geriatrics, Hacettepe University, 06280, Ankara, Turkey;

关键词: Dysphagia;    Frailty;    Dementia;    Quality of life;   

DOI  :  10.1186/s12877-023-04020-y

 received in 2023-03-21, accepted in 2023-05-05,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionPhysical phenotype and the cumulative deficit model are two well-known concepts of frailty. One of the main components of frailty is loss of muscle mass and function, which may also include swallowing muscles, therefore is a risk factor for dysphagia. Since dysphagia is seen starting from the early stages of Alzheimer’s Disease (AD), in this study we aimed to reveal the relationship between frailty and dysphagia and dysphagia-related quality of life through Swallow Quality of Life (SwalQoL) tool in patients with AD and compare them with cognitively intact older adults.MethodsComprehensive geriatric assessment, dysphagia evaluation by Eating-Assessment Tool (EAT-10) and SwalQoL questionnaire, and frailty assessment via FRAIL and Clinical Frailty Scale (CFS) were performed on all 101 participants of the study. Thirty-five patients were cognitively intact, 36 patients were diagnosed with mild AD, and 30 patients were diagnosed with moderate AD.ResultsSex distribution was similar between the groups, however, there was a statistically significant age difference. The prevalence of frailty increased according to both frailty indexes as the cognitive status deteriorated. All parameters of SwalQoL except fear and sleep parameters deteriorated as cognitive status impaired. In quantile regression of the total score of the SwalQoL questionnaire and multivariable logistic regression of EAT-10, frailty, as defined by CFS and FRAIL, was associated with dysphagia and poor quality of life regardless of age, presence of dementia, as well as nutritional status.ConclusionSwallowing difficulties in AD negatively affects the quality of life, and it is closely related to frailty in mild-to-moderate AD.

【 授权许可】

CC BY   
© The Author(s) 2023