Is mechanical power an under-recognised entity within the preterm lung?

Intensive Care Medicine Experimental

Hypothesis

Tobias Becher¹  Martin C. J. Kneyber²  Hamish D. Tingay³  Hannah Naidu³  Prue M. Pereira-Fantini⁴  David G. Tingay⁵ 

[1] Department of Anesthesiology and Intensive Care Medicine, University Medical Centre Schleswig–Holstein, Campus Kiel, Arnold-Heller-Straße 3, Haus R3, 24105, Kiel, Germany;Division of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, Groningen, The Netherlands;Critical Care, Anaesthesiology, Peri-Operative and Emergency Medicine, The University of Groningen, Groningen, The Netherlands;Neonatal Research, Murdoch Children’s Research Institute, Parkville, Australia;Neonatal Research, Murdoch Children’s Research Institute, Parkville, Australia;Department of Paediatrics, University of Melbourne, Melbourne, Australia;Neonatal Research, Murdoch Children’s Research Institute, Parkville, Australia;Department of Paediatrics, University of Melbourne, Melbourne, Australia;Department of Neonatology, The Royal Children’s Hospital, Parkville, Australia;

关键词: Infant;    Preterm;    Mechanical ventilation;    Mechanical power;    Lung mechanics;    Ventilator-induced lung injury;   

DOI  :  10.1186/s40635-023-00511-9

 received in 2023-01-12, accepted in 2023-04-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMechanical power is a major contributor to lung injury and mortality in adults receiving mechanical ventilation. Recent advances in our understanding of mechanical power have allowed the different mechanical components to be isolated. The preterm lung shares many of the same similarities that would indicate mechanical power may be relevant in this group. To date, the role of mechanical power in neonatal lung injury is unknown. We hypothesise that mechanical power maybe useful in expanding our understanding of preterm lung disease. Specifically, that mechanical power measures may account for gaps in knowledge in how lung injury is initiated.Hypothesis-generating data setTo provide a justification for our hypothesis, data in a repository at the Murdoch Children’s Research Institute, Melbourne (Australia) were re-analysed. 16 preterm lambs 124–127d gestation (term 145d) who received 90 min of standardised positive pressure ventilation from birth via a cuffed endotracheal tube were chosen as each was exposed to three distinct and clinically relevant respiratory states with unique mechanics. These were (1) the respiratory transition to air-breathing from an entirely fluid-filled lung (rapid aeration and fall in resistance); (2) commencement of tidal ventilation in an acutely surfactant-deficient state (low compliance) and (3) exogenous surfactant therapy (improved aeration and compliance). Total, tidal, resistive and elastic-dynamic mechanical power were calculated from the flow, pressure and volume signals (200 Hz) for each inflation.ResultsAll components of mechanical power behaved as expected for each state. Mechanical power increased during lung aeration from birth to 5 min, before again falling immediately after surfactant therapy. Before surfactant therapy tidal power contributed 70% of total mechanical power, and 53.7% after. The contribution of resistive power was greatest at birth, demonstrating the initial high respiratory system resistance at birth.ConclusionsIn our hypothesis-generating dataset, changes in mechanical power were evident during clinically important states for the preterm lung, specifically transition to air-breathing, changes in aeration and surfactant administration. Future preclinical studies using ventilation strategies designed to highlight different types of lung injury, including volu-, baro- and ergotrauma, are needed to test our hypothesis.

【 授权许可】

CC BY   
© The Author(s) 2023

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