Evaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial

Trials

Study Protocol

Noboru Minakawa¹  Wataru Kagaya²  Laura Barbieri²  Protus Omondi²  James Kongere²  Chim W. Chan²  Achyut Kc³  Akira Kaneko⁴  Jesse Gitaka⁵  Bernard N. Kanoi⁵  Mtakai Ngara⁶  Ashley Osborne⁷ 

[1] Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden;Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden;Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;Directorate of Research and Innovation, Mount Kenya University, Thika, Kenya;Directorate of Research and Innovation, Mount Kenya University, Thika, Kenya;Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden;Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK;

关键词: Malaria;    Anopheles;    Vector control;    LLIN;    Pyrethroid resistance;    Ceiling net;    Kenya;    Cluster-randomized controlled trial;   

DOI  :  10.1186/s13063-023-07372-3

 received in 2023-03-30, accepted in 2023-05-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundIn the Lake Victoria Basin of western Kenya, malaria remains highly endemic despite high coverage of interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective effect of LLINs is hampered by insecticide resistance in Anopheles vectors and its repurposing by the community. Ceiling nets and LLIN with synergist piperonyl butoxide (PBO-LLIN) are novel tools that can overcome the problems of behavioral variation of net use and metabolic resistance to insecticide, respectively. The two have been shown to reduce malaria prevalence when used independently. Integration of these two tools (i.e., ceiling nets made with PBO-LLIN or Olyset®Plus ceiling nets) appears promising in further reducing the malaria burden.MethodsA cluster-randomized controlled trial is designed to assess the effect of Olyset®Plus ceiling nets on reducing malaria prevalence in children on Mfangano Island in Homa Bay County, where malaria transmission is moderate. Olyset®Plus ceiling nets will be installed in 1315 residential structures. Malaria parasitological, entomological, and serological indicators will be measured for 12 months to compare the effectiveness of this new intervention against conventional LLIN in the control arm.DiscussionWider adoption of Olyset®Plus ceiling nets to complement existing interventions may benefit other malaria-endemic counties and be incorporated as part of Kenya’s national malaria elimination strategy.Trial registrationUMIN Clinical Trials Registry UMIN000045079. Registered on 4 August 2021.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 2