Anti-synthetase syndrome-associated interstitial lung disease possibly caused by atezolizumab in a patient with lung adenocarcinoma: a case report

BMC Pulmonary Medicine

Case Report

Ryo Kusahana¹  Yasuhiro Gon¹  Yoshiko Nakagawa¹  Ippei Miyamoto¹  Daishi Fujiwara¹  Tetsuo Shimizu¹  Masayuki Nomoto¹  Tsukasa Nishizawa¹  Kentaro Hayashi¹ 

[1] Department of Respiratory Medicine, Nihon University Itabashi Hospital, Nihon University School of Medicine, 30-1, Oyaguchi-Kamicho, Itabashi-Ku, 173-8610, Tokyo, Japan;

关键词: Aminoacyl-tRNA synthetase (ARS);    Anti-synthetase syndrome (ASS);    Interstitial lung disease;    Lung cancer;    Immune checkpoint inhibitors (ICIs);   

DOI  :  10.1186/s12890-023-02446-z

 received in 2022-11-01, accepted in 2023-04-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAnti-aminoacyl-tRNA synthetase (ARS) antibody-positive patients present with a variety of symptoms, including interstitial lung disease (ILD), which is termed anti-synthetase syndrome (ASS). But it is rare that ASS-ILD is considered an immune-related adverse event after the use of immune checkpoint inhibitors (ICIs).Case presentationA 47-year-old male with advanced lung adenocarcinoma was treated with platinum and ICI combination immunotherapy and was followed up as an outpatient. Nine months after the start of treatment, he developed a fever and cough, and imaging findings showed lung consolidations in the bilateral lower lung fields. The patient was positive for anti- ARS antibodies and was considered to have developed ASS-ILD due to ICIs remitted with steroid therapy. The patient was found to be positive for anti-ARS antibodies before ICI administration, and the antibody titer was elevated compared to that before ICI administration.ConclusionsThe examination of anti-ARS antibodies pior to the administration of ICIs may be useful in predicting the development of ASS-ILD.

【 授权许可】

CC BY   
© The Author(s) 2023

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